ArticleCancer medicine2022
Effects of surgery on survival of patients aged 75 years or older with Merkel cell carcinoma.
Article in Cancer medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Article
- Predictive and Interpretable Machine Learning of Economic Burden: The Role of Chronic Conditions Among Elderly Patients with Incident Primary Merkel Cell Carcinoma (MCC).ClinicoEconomics and outcomes research : CEOR · 2024Article
- Effects of surgery on survival of patients aged 75 years or older with Merkel cell carcinoma.Cancer medicine · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether surgery improves prognosis in elderly patients with Merkel cell carcinoma (MCC). MATERIALS/
methodsData of all patients with MCC diagnosed between 2004 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Differences in baseline characteristics were analyzed among the age groups (75-80, 80-85, and ≥85 years). Multivariate Cox proportional hazards analysis was used to assess the effects of each variable on patient outcomes. The Kaplan-Meier curves were employed to evaluate MCC overall survival (OS) and MCC-specific survival (MSS).
resultsA total of 1156 of patients with MCC met the inclusion and exclusion criteria. The surgery rate decreased with age (75-80, 80-85, and ≥85 years were 93.3%, 91.1%, and 88.7%, respectively; p = 0.082). Multivariate Cox proportional hazards analysis showed that the OS of patients in the 80-85 years group (hazard ratio [HR] = 1.39; 95% confidence interval [CI] = 1.14-1.70; p = 0.001) and the ≥85 years group (HR = 2.18; 95% CI = 1.80-2.63; p < 0.0001) was worse than that in the 75-80 years group. Compared with the non-surgery groups, the HR for the surgery group was 0.75 for OS (95% CI = 0.56-1.00; p = 0.048) and 0.73 for MSS (95% CI = 0.48-1.10; p = 0.130). Subgroup analyses showed that patients aged ≥85 years undergoing surgery had better OS (HR = 0.65; 95% CI = 0.45-0.95; p = 0.024).
conclusionsMCC patients aged 75 years and older would benefit from surgical resection. However, surgical resection should be performed cautiously, and larger prospective clinical trials are needed to further verify these findings.
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