ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2021
Exploring the genetic overlap of suicide-related behaviors and substance use disorders.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Genetics and epigenetics of self-injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022Pooled it
- Lifetime substance use disorder and suicidal behaviour: a population-based familial co-aggregation register study.Molecular psychiatry · 2026Article
- Elucidating psychosocial outcome profiles as a function of aggregate genetic risk for suicide attempt and alcohol use disorder.Translational psychiatry · 2026Article
- High Prevalence of Suicidal Behavior in Severe Alcohol Use Disorder Linked to Specific Neurocognitive Deficits: The Cognition, Alcohol, Genes, and Environment Study.Journal of studies on alcohol and drugs · 2026Article
- Suicidality phenotypes reflect both shared and distinct genetic factors.medRxiv : the preprint server for health sciences · 2026Article
- Characterizing the co-occurrence of alcohol experimentation and suicidal thoughts and behaviors in early adolescence.Translational psychiatry · 2026Article
- Suicide attempts among Korean adolescents before, during and after the COVID-19 pandemic: a cross-sectional study.BMJ open · 2026Article
- Review
- Associations between cannabis use frequency and suicidal thoughts and behaviors: A clinical longitudinal sibling study.Addictive behaviors reports · 2025Article
- Genome-wide association studies identify 77 loci for suicidality and provide novel biological insights.medRxiv : the preprint server for health sciences · 2025Article
- Article
- A Multivariate Genomic Investigation of the Externalizing Spectrum and Suicide Risk.medRxiv : the preprint server for health sciences · 2025Article
- Distinguishing clinical and genetic risk factors for suicidal ideation and behavior in a diverse hospital population.Translational psychiatry · 2025Article
- The genetic landscape of substance use disorders.Molecular psychiatry · 2024Review
- Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder.medRxiv : the preprint server for health sciences · 2024Article
- Risk of suicidal behavior as a function of alcohol use disorder typologies: A Swedish population-based study.Addiction (Abingdon, England) · 2024Article
- The role of substance use disorders in the transition from suicide attempt to suicide death: a record linkage study of a Swedish cohort.Psychological medicine · 2024Article
- The collaborative study on the genetics of alcoholism: Sample and clinical data.Genes, brain, and behavior · 2023Review
- Cross-phenotype relationship between opioid use disorder and suicide attempts: new evidence from polygenic association and Mendelian randomization analyses.Molecular psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Suicide-related behaviors are heterogeneous and transdiagnostic, and may demonstrate varying levels of genetic overlap with different substance use disorders (SUDs). We used linkage disequilibrium score regression, genomic structural equation models, and Mendelian randomization to examine the genetic relationships between several SUDs and suicide-related behaviors. Our analyses incorporated summary statistics from the largest genome-wide association studies (GWAS) of problematic alcohol use, the Fagerström test for nicotine dependence, cannabis use disorder, and opioid use disorder (Ns ranging from 46,213-435,563) and GWAS of ever self-harmed, suicide attempt, and suicide death (Ns ranging from 18,223-117,733). We also accounted for genetic liability to depression (N = 500,199) and risk tolerance (N = 315,894). Suicide-related behaviors were significantly genetically correlated with each other and each SUD, but there was little evidence of causal relationships between the traits. Simultaneously correlating a common SUD factor with each specific suicide indicator while controlling for depression and risk tolerance revealed significant, positive genetic correlations between the SUD factor and suicide-related behaviors (r
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.