Evidence map›Paper›PMID 34820908›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Soluble very low-density lipoprotein receptor (sVLDLR) inhibits fibrosis in neovascular age-related macular degeneration.

Xiang Ma, Yusuke Takahashi, Wenjing Wu, Jianglei Chen, Marcus Dehdarani, Wentao Liang, Young-Hwa Shin, Siribhinya Benyajati, Jian-Xing Ma

Open access · hybridAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
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  12. Soluble very low-density lipoprotein receptor (sVLDLR) inhibits fibrosis in neovascular age-related macular degeneration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xiang MaDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Yusuke TakahashiDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Wenjing WuDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Jianglei ChenDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Marcus DehdaraniDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Wentao LiangDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Young-Hwa ShinDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Siribhinya BenyajatiDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Jian-Xing MaDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
University of Oklahoma Health Sciences Center · US

Funding

P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan, MICHAEL H ELLIOTT · 2011 to 2026
$10.5M
A new pathogenic mechanism for diabetic retinopathyR01EY019309 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jian-Xing Jay Ma · 2009 to 2026
$6.1M
STUDIES OF RPE65R01EY012231 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MA, JIAN-XING, MOISEYEV, GENNADIY · 1998 to 2021
$5.7M
Pilot Project ProgramP30GM122744 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LE, YUN ZHENG · 2017 to 2021
$5.5M
A Novel Pathogenic Pathway for Diabetic KeratopathyR01EY028949 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Dimitrios Karamichos, Jian-Xing Jay Ma · 2018 to 2026
$2.2M
Dysregulation of Wnt signaling in subretinal fibrosis in AMDR01EY032931 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI TAKAHASHI, YUSUKE · 2021 to 2025
$1.9M
Studies of retinyl ester hydrolase in the visual cycleR01EY032930 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MA, JIAN-XING JAY, MOISEYEV, GENNADIY · 2021 to 2025
$1.9M
NEI NIH HHS P30 EY021725NEI NIH HHS R01 EY012231NEI NIH HHS R01 EY019309NEI NIH HHS R01 EY028949NEI NIH HHS R01 EY032930NEI NIH HHS R01 EY032931NIGMS NIH HHS P30 GM122744
6 · The paper itself

Abstract

Subretinal fibrosis is a key pathological feature in neovascular age-related macular degeneration (nAMD). Previously, we identified soluble very low-density lipoprotein receptor (sVLDLR) as an endogenous Wnt signaling inhibitor. This study investigates whether sVLDLR plays an anti-fibrogenic role in nAMD models, including Vldlr

Indexed as

Disease Models, AnimalAnimalsCells, CulturedChoroidal NeovascularizationConnective Tissue Growth FactorCRISPR-Cas SystemsFibrosisLow Density Lipoprotein Receptor-Related Protein-6Macular DegenerationMiceMice, Inbred C57BLMice, KnockoutReceptors, LDLRetinal Pigment EpitheliumSmad ProteinsTransforming Growth Factor betaCCN2 protein, humanConnective Tissue Growth FactorLow Density Lipoprotein Receptor-Related Protein-6LRP6 protein, humanReceptors, LDLSmad ProteinsTransforming Growth Factor betaVLDL receptorfibrosismacular degenerationTGF-β signaling pathwayvery low-density lipoprotein receptorWnt signaling pathway

Identifiers

PMID34820908
PMCPMC9131420
OpenAlexW3215485559

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.