Evidence map›Paper›PMID 34820895›Full record

ReviewJournal of gastroenterology and hepatology2022

The microbiome, gastrointestinal cancer, and immunotherapy.

Rachel C Newsome, Ye Yang, Christian Jobin

Abstract readReview
In one paragraph

Review in Journal of gastroenterology and hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Effect ofImmunotherapy · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Autophagy in gastrointestinal cancers.Frontiers in oncology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rachel C NewsomeDepartment of Medicine, University of Florida, Gainesville, Florida, USA.
Ye YangDepartment of Medicine, University of Florida, Gainesville, Florida, USA.ORCID https://orcid.org/0000-0002-7576-3067
Christian JobinDepartment of Medicine, University of Florida, Gainesville, Florida, USA.ORCID https://orcid.org/0000-0002-3733-1001

Funding

The role of klebsiella pneumonia-derived colibactin in colitis-associated colon cancerR01DK073338 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOBIN, CHRISTIAN · 2007 to 2023
$5.4M
Team-based Interdisciplinary Cancer Research Training ProgramT32CA257923 · NCI · UNIVERSITY OF FLORIDA · PI SIEMANN, DIETMAR W · 2021 to 2025
$1.2M
NCI NIH HHS T32 CA257923NIDDK NIH HHS R01 DK073338
6 · The paper itself

Abstract

The gastrointestinal tract greatly contributes to global cancer burden and cancer-related deaths. The microbiota represents the population of microorganisms that live in and around the body, located primarily in the gastrointestinal tract. The microbiota has been implicated in colorectal cancer development and progression, but its role in cancer therapy for the gastrointestinal tract is less defined, especially for extra-intestinal cancers. In this review, we discuss the past 5 years of research into microbial involvement in immune-related therapies for colorectal, pancreatic, hepatic, and gastric cancers, with the goal of highlighting recent advances and new areas for investigation in this field.

Indexed as

Gastrointestinal MicrobiomeGastrointestinal NeoplasmsImmunotherapyHumansantitumor immunitycolorectal cancerliver cancermicrobiotapancreatic cancer

Identifiers

PMID34820895
PMCPMC9922516

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.