Evidence map›Paper›PMID 34820829›Full record

ArticleBritish journal of pharmacology2022

Alzheimer's disease and cerebrovascular pathology alter inward rectifier potassium (K

María Lacalle-Aurioles, Lianne J Trigiani, Miled Bourourou, Clotilde Lecrux, Edith Hamel

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in British journal of pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Perivascular brain clearance as a therapeutic target in cerebral amyloid angiopathy and Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  6. Review
  7. Review
  8. Vascular Function and Ion Channels in Alzheimer's Disease.Microcirculation (New York, N.Y. : 1994) · 2024
    Review
  9. Review
  10. Review
  11. Alterations of the blood-brain barrier during aging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  17. Article
  18. Uncoupling of CaProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. KMicrocirculation (New York, N.Y. : 1994) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

María Lacalle-AuriolesLaboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-1054-2498
Lianne J TrigianiLaboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-6332-7903
Miled BourourouLaboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-1466-6554
Clotilde LecruxLaboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-3521-5266
Edith HamelLaboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0001-5223-7315
Montreal Neurological Institute and Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeInward rectifier potassium (K EXPERIMENTAL APPROACH: We evaluated K KEY

resultsOur findings show that (i) K CONCLUSION AND IMPLICATIONS: Therapies targeting both oxidative stress and inflammation are necessary for full recovery of K

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsCerebral ArteriesCerebrovascular CirculationEndothelial CellsEndotheliumMiceMice, TransgenicPotassiumPotassium Channels, Inwardly RectifyingAmyloid beta-PeptidesKir2.1 channelPotassiumPotassium Channels, Inwardly Rectifyingcerebral blood flowcerebrovascular reactivityendotheliuminflammationneuronal activityneurovascular couplingoxidative stress

Identifiers

PMID34820829
PMCPMC9304142
OpenAlexW3216899506

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.