ArticleDigestive diseases and sciences2022
Relationship Between Body Composition and Death in Patients with COVID-19 Differs Based on the Presence of Gastrointestinal Symptoms.
Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Prevalence and clinical implications of abnormal body composition phenotypes in patients with COVID-19: a systematic review.The American journal of clinical nutrition · 2023Pooled it
- Improved Survival in Malnourished COVID-19 Inpatients with Oral Nutrition Supplementation.Nutrients · 2025Article
- Proton pump inhibitors and gastrointestinal symptoms among patients with COVID-19 infection.Annals of medicine · 2024Article
- Visceral Adiposity Independently Predicts Time to Flare in Inflammatory Bowel Disease but Body Mass Index Does Not.Inflammatory bowel diseases · 2024Article
- Article
- Sarcopenia and Mortality in Critically Ill COVID-19 Patients.Life (Basel, Switzerland) · 2023Review
- Visceral to subcutaneous fat ratio predicts short-term mortality in patients with Covid 19. A multicenter study.The British journal of radiology · 2023Article
- Assessment of body composition in adults hospitalized with acute COVID-19: a scoping review.Frontiers in nutrition · 2023Article
- Malnutrition Increases Hospital Length of Stay and Mortality among Adult Inpatients with COVID-19.Nutrients · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPatients with SARS-CoV-2 who present with gastrointestinal symptoms have a milder clinical course than those who do not. Risk factors for severe COVID-19 disease include increased adiposity and sarcopenia.
aimsTo determine whether body composition risk factors are associated with worse outcomes among patients with gastrointestinal symptoms.
methodsThis was a retrospective study of hospitalized patients with COVID-19 who underwent abdominal CT scan for clinical indications. Abdominal body composition measures including skeletal muscle index (SMI), intramuscular adipose tissue index (IMATI), visceral adipose tissue index (VATI), subcutaneous adipose tissue index (SATI), visceral-to-subcutaneous adipose tissue ratio (VAT/SAT ratio), and liver and spleen attenuation were collected. The association between body composition measurements and 30-day mortality was evaluated in patients with and without gastrointestinal symptoms at the time of positive SARS-CoV-2 test.
resultsAbdominal CT scans of 190 patients with COVID-19 were evaluated. Gastrointestinal symptoms including nausea, vomiting, diarrhea, or abdominal pain were present in 117 (62%). Among patients without gastrointestinal symptoms, those who died had greater IMATI (p = 0.049), less SMI (p = 0.010), and a trend toward a greater VAT/SAT ratio. Among patients with gastrointestinal symptoms, those who died had significantly greater IMATI (p = 0.025) but no differences in other measures.
conclusionsAmong patients with COVID-19, those without gastrointestinal symptoms showed the expected associations between mortality and low SMI, high IMATI, and trend toward higher VAT/SAT ratio, but those with gastrointestinal symptoms did not. Future studies should explore the mechanisms for the altered disease course in patients with COVID-19 who present with gastrointestinal symptoms.
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