ReviewJournal of mass spectrometry and advances in the clinical lab2021
Poisoning by organophosphorus nerve agents and pesticides: An overview of the principle strategies and current progress of mass spectrometry-based procedures for verification.
Review in Journal of mass spectrometry and advances in the clinical lab, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- p-Nitrophenoxy analogs as practical surrogates for Novichok-related biomarker verification in forensic toxicology.Forensic toxicology · 2026Article
- Direct Mass Spectrometric Detection of VX, RVX, and Novichok A-Series Nerve Agents for Screening Contaminated Sites Using Atmospheric Pressure Corona Discharge Ionization.Analytical chemistry · 2026Article
- Toxic Tear Gas 2-Chloroacetophenone (CN) Forms Adducts With Endogenous Plasma Thiols In Vitro Valuable as Biomarkers of Exposure.Drug testing and analysis · 2026Article
- Evaluation of dried blood spot sampling for verification of exposure to chemical threat agents.Forensic toxicology · 2025Article
- Phosphonylated tyrosine and cysteine disulfide adducts both generated from immunoglobulin G and human serum albumin indicate exposure to the nerve agent VX in vitro.Analytical and bioanalytical chemistry · 2025Article
- Hemoadsorption: a new tool in neurotoxic poisoning.Frontiers in nephrology · 2025Review
- Progressive expansion of albumin adducts for organophosphorus nerve agent traceability based on single and group adduct collection.Analytical and bioanalytical chemistry · 2024Article
- Trauma-toxicology: concepts, causes, complications.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Development of a molecularly imprinted polymer-based electrochemical sensor for the selective detection of nerve agent VX metabolite ethyl methylphosphonic acid in human plasma and urine samples.Analytical and bioanalytical chemistry · 2024Article
- The phosphylated butyrylcholinesterase-derived tetrapeptide GlyGluSerAla proves exposure to organophosphorus agents with enantioselectivity.Archives of toxicology · 2024Article
- Influence of sequential blood purification therapy on myocardial injury and serum inflammatory cytokine levels in patients with organophosphate poisoning.American journal of translational research · 2024Article
- HI-6-loaded PEGylated liposomes: an on-site first-aid strategy for acute organophosphorus agent poisoning.Drug delivery · 2023Article
- Monitoring Exposure to Five Chemical Warfare Agents Using the Dried Urine Spot Technique and Liquid Chromatography-Mass Spectrometry/Mass Spectrometry-In Vivo Determination of Sarin Metabolite in Mice.Molecules (Basel, Switzerland) · 2023Article
- Evidence of nerve agent VX exposure in rat plasma by detection of albumin-adducts in vitro and in vivo.Archives of toxicology · 2023Article
- A clinical approach to an unidentified aerosolized bioterrorism agent: a narrative review for emergency providers.Clinical and experimental emergency medicine · 2023Article
- A portable acetylcholinesterase-based electrochemical sensor for field detection of organophosphorus.RSC advances · 2023Article
- Selected Political Criminal Poisonings in the Years 1978-2020: Detection and Treatment.Toxics · 2022Review
- A case report of severe pirimiphos-methyl intoxication: Clinical findings and cholinesterase status.Frontiers in pharmacology · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intoxication by organophosphorus (OP) poisons, like nerve agents and pesticides, is characterized by the life-threatening inhibition of acetylcholinesterase (AChE) caused by covalent reaction with the serine residue of the active site of the enzyme (phosphylation). Similar reactions occur with butyrylcholinesterase (BChE) and serum albumin present in blood as dissolved proteins. For forensic purposes, products (adducts) with the latter proteins are highly valuable long-lived biomarkers of exposure to OP agents that are accessible by diverse mass spectrometric procedures. In addition, the evidence of poison incorporation might also succeed by the detection of remaining traces of the agent itself, but more likely its hydrolysis and/or enzymatic degradation products. These relatively short-lived molecules are distributed in blood and tissue, and excreted via urine. This review presents the mass spectrometry-based methods targeting the different groups of biomarkers in biological samples, which are already internationally accepted by the Organisation for the Prohibition of Chemical Weapons (OPCW), introduces novel approaches in the field of biomedical verification, and outlines the strict quality criteria that must be fulfilled for unambiguous forensic analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.