Evidence map›Paper›PMID 34820636›Full record

ArticleCurrent research in neurobiology2021

Cholinergic modulation of hierarchical inhibitory control over cortical resting state dynamics: Local circuit modeling of schizophrenia-related hypofrontality.

Marie Rooy, Ivan Lazarevich, Fani Koukouli, Uwe Maskos, Boris Gutkin

Abstract read
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In one paragraph

Article in Current research in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marie RooyEcole Normale Sup'erieure PSL Univeristy, Laboratoire de Neurosciences Cognitives INSERM U960, Group for Neural Theory, Paris, France.
Ivan LazarevichEcole Normale Sup'erieure PSL Univeristy, Laboratoire de Neurosciences Cognitives INSERM U960, Group for Neural Theory, Paris, France.
Fani KoukouliInstitut Pasteur, Neurobiologie integrative des systemes cholinergiques, Paris, France.
Uwe MaskosInstitut Pasteur, Neurobiologie integrative des systemes cholinergiques, Paris, France.
Boris GutkinEcole Normale Sup'erieure PSL Univeristy, Laboratoire de Neurosciences Cognitives INSERM U960, Group for Neural Theory, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotinic acetylcholine receptors (nAChRs) modulate the cholinergic drive to a hierarchy of inhibitory neurons in the superficial layers of the PFC, critical to cognitive processes. It has been shown that genetic deletions of the various types of nAChRs impact the properties of ultra-slow transitions between high and low PFC activity states in mice during quiet wakefulness. The impact characteristics depend on specific interneuron populations expressing the manipulated receptor subtype. In addition, recent data indicate that a genetic mutation of the

Indexed as

Computational modellingHierarchical inhibitory circuitryHypofrontalityLocal cortical circuit mechanismsNicotinic receptorsSchizophrenia

Identifiers

PMID34820636
PMCPMC8591733

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.