Evidence map›Paper›PMID 34820606›Full record

ArticleiScience2021

Myeloid cell subsets that express latency-associated peptide promote cancer growth by modulating T cells.

Galina Gabriely, Duanduan Ma, Shafiuddin Siddiqui, Linqing Sun, Nathaniel P Skillin, Hadi Abou-El-Hassan, Thais G Moreira, Dustin Donnelly, Andre P da Cunha, Mai Fujiwara and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Galina GabrielyAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Duanduan MaMIT Biomicro Center, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Shafiuddin SiddiquiFlow Cytometry Core Facility, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Drive, Bethesda, MD 20892-4255, USA.
Linqing SunAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Nathaniel P SkillinAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Hadi Abou-El-HassanAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Thais G MoreiraAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Dustin DonnellyAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Andre P da CunhaAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Mai FujiwaraAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Lena R WaltonAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Amee PatelAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Rajesh KrishnanAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Stuart S LevineMIT Biomicro Center, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Brian C HealyAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Rafael M RezendeAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Gopal MurugaiyanAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Howard L WeinerAnn Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Brigham and Women's Hospital · USMassachusetts Institute of Technology · USNational Cancer Institute · USNorthwestern University · US

Funding

MICRORNA CONTROL OF INFLAMMATORY AND REGULATORY T CELLS IN CENTRAL NERVOUS SYSTEM AUTOIMMUNITYR01AI127853 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOPAL, MURUGAIYAN · 2017 to 2021
$2.2M
The pathogenic role of miR-92a in the regulation of T helper cell responses in EAE and MSR01AI151953 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOPAL, MURUGAIYAN · 2020 to 2024
$2.1M
MicroRNA control of tumor-promoting inflammation in colon cancerR01CA267479 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Murugaiyan Gopal · 2022 to 2026
$1.9M
Development of novel PD1 agonist therapeutic strategies for multiple sclerosisR21AI174047 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOPAL, MURUGAIYAN · 2023 to 2024
$442k
NCI NIH HHS R01 CA267479NIAID NIH HHS R01 AI127853NIAID NIH HHS R01 AI151953NIAID NIH HHS R21 AI174047
6 · The paper itself

Abstract

Myeloid suppressor cells promote tumor growth by a variety of mechanisms which are not fully characterized. We identified myeloid cells (MCs) expressing the latency-associated peptide (LAP) of TGF-β on their surface and LAP

Indexed as

CancerImmunology

Identifiers

PMID34820606
PMCPMC8602030
OpenAlexW3210219649

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.