Evidence map›Paper›PMID 34820593›Full record

ArticleJCO precision oncology2021

Iris van 't Erve, Nina J Wesdorp, Jamie E Medina, Leonardo Ferreira, Alessandro Leal, Joost Huiskens, Karen Bolhuis, Jan-Hein T M van Waesberghe, Rutger-Jan Swijnenburg, Daan van den Broek and 5 more

Open access · hybridAbstract read
In one paragraph

Article in JCO precision oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. KRASCellular & molecular biology letters · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Tumor-derived RAC1Science advances · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Iris van 't ErveDepartment of Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.ORCID 0000-0003-3667-9185
Nina J WesdorpDeparment of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands.
Jamie E MedinaSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-6124-0548
Leonardo FerreiraSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-2468-2689
Alessandro LealSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0001-7967-3213
Joost HuiskensSAS Institute B.V., Huizen, the Netherlands.ORCID 0000-0002-0774-1042
Karen BolhuisDepartment of Medical Oncology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
Jan-Hein T M van WaesbergheDeparment of Radiology and Molecular Imaging, Cancer Center Amsterdam, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands.
Rutger-Jan SwijnenburgDeparment of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands.
Daan van den BroekDepartment for Laboratory Medicine, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Victor E VelculescuSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0003-1195-438X
Geert KazemierDeparment of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands.
Cornelis J A PuntDepartment of Medical Oncology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
Gerrit A MeijerDepartment of Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Remond J A FijnemanDepartment of Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.ORCID 0000-0003-2076-5521
Amsterdam University Medical Centers · NLJohns Hopkins University · USThe Netherlands Cancer Institute · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Somatic

methodsA total of 419 patients with colorectal cancer with initially unresectable liver-limited metastases, who participated in a multicenter prospective trial, were evaluated for tumor tissue

resultsMost patients carried a

conclusionPatients with mCRC with a

Indexed as

AgedAnalysis of VarianceColorectal NeoplasmsFemaleHumansLiver NeoplasmsMaleMiddle AgedMutationNeoplasm MetastasisPrognosisProto-Oncogene Proteins p21(ras)KRAS protein, humanProto-Oncogene Proteins p21(ras)

Identifiers

PMID34820593
PMCPMC8608264
OpenAlexW3212975451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.