Evidence map›Paper›PMID 34820589›Full record

ReviewBioactive materials2022

Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications.

Tejal V Patil, Dinesh K Patel, Sayan Deb Dutta, Keya Ganguly, Tuhin Subhra Santra, Ki-Taek Lim

Abstract readReview
In one paragraph

Review in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

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  17. Stimulus-Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tejal V PatilDepartment of Biosystems Engineering, Institute of Forest Science, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Dinesh K PatelDepartment of Biosystems Engineering, Institute of Forest Science, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Sayan Deb DuttaDepartment of Biosystems Engineering, Institute of Forest Science, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Keya GangulyDepartment of Biosystems Engineering, Institute of Forest Science, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Tuhin Subhra SantraDeptarment of Engineering Design, Indian Institute of Technology, Madras, 600036, India.
Ki-Taek LimDepartment of Biosystems Engineering, Institute of Forest Science, Kangwon National University, Chuncheon, 24341, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanocellulose, a biopolymer, has received wide attention from researchers owing to its superior physicochemical properties, such as high mechanical strength, low density, biodegradability, and biocompatibility. Nanocellulose can be extracted from wide range of sources, including plants, bacteria, and algae. Depending on the extraction process and dimensions (diameter and length), they are categorized into three main types: cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial nanocellulose (BNC). CNCs are a highly crystalline and needle-like structure, whereas CNFs have both amorphous and crystalline regions in their network. BNC is the purest form of nanocellulose. The nanocellulose properties can be tuned by chemical functionalization, which increases its applicability in biomedical applications. This review highlights the fabrication of different surface-modified nanocellulose to deliver active molecules, such as drugs, proteins, and plasmids. Nanocellulose-mediated delivery of active molecules is profoundly affected by its topographical structure and the interaction between the loaded molecules and nanocellulose. The applications of nanocellulose and its composites in tissue engineering have been discussed. Finally, the review is concluded with further opportunities and challenges in nanocellulose-mediated delivery of active molecules.

Indexed as

Chemical functionalizationDrug deliveryNanocellulosePlasmid deliveryProtein deliveryTissue engineering

Identifiers

PMID34820589
PMCPMC8591404

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.