ReviewBioactive materials2022
Key considerations on the development of biodegradable biomaterials for clinical translation of medical devices: With cartilage repair products as an example.
Review in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Hydrogen releasing biomaterials for bone regeneration: mechanisms, design strategies, and applications.Bioactive materials · 2027Review
- Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Innovative Hydroxyapatite-Hydrogel Composites for Cartilage Regeneration.Gels (Basel, Switzerland) · 2026Review
- Advanced therapy medicinal product (ATMP) classification - a case study on spinal cord injury.Journal of translational medicine · 2026Review
- Biomimetic Design of Dental Restorative Materials: Conceptual Framework and Translational Challenges.Biomimetics (Basel, Switzerland) · 2026Review
- Innovative Technologies for Articular Cartilage Repair: Research, Development, and Clinical Translation-A Narrative Review.Journal of functional biomaterials · 2026Review
- Advances in biomimetic mineralized biomaterials for bone tissue engineering.Regenerative biomaterials · 2026Review
- Advanced engineering strategies for biomaterial scaffolds application in tendon-bone interface regeneration.Burns & trauma · 2026Review
- Point-of-care bone cement based on natural peptide comonomer protects orthopaedic implants from bacterial challenge.Materials today. Bio · 2025Article
- Materiobiology in the omics era.Materials today. Bio · 2025Review
- Autonomous Implants.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Strategies for promoting neurovascularization in bone regeneration.Military Medical Research · 2025Review
- Biomolecular Microneedle Initiates FeAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Next-Generation Biomaterials for Wound Healing: Development and Evaluation of Collagen Scaffolds Functionalized with a Heparan Sulfate Mimic and Fibroblast Growth Factor 2.Journal of functional biomaterials · 2025Article
- Charting a quarter-century of commercial cartilage regeneration products.Journal of orthopaedic translation · 2025Review
- Modeling of Magnetic Scaffolds as Drug Delivery Platforms for Tissue Engineering and Cancer Therapy.Bioengineering (Basel, Switzerland) · 2024Article
- Recent advancements in cartilage tissue engineering innovation and translation.Nature reviews. Rheumatology · 2024Review
- Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Characterization of a decellularized pericardium extracellular matrix hydrogel for regenerative medicine: insights on animal-to-animal variability.Frontiers in bioengineering and biotechnology · 2024Article
- Advances in Bioresorbable Triboelectric Nanogenerators.Chemical reviews · 2023Review
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the interdisciplinary convergence of biology, medicine and materials science, both research and clinical translation of biomaterials are progressing at a rapid pace. However, there is still a huge gap between applied basic research on biomaterials and their translational products - medical devices, where two significantly different perspectives and mindsets often work independently and non-synergistically, which in turn significantly increases financial costs and research effort. Although this gap is well-known and often criticized in the biopharmaceutical industry, it is gradually widening. In this article, we critically examine the developmental pipeline of biodegradable biomaterials and biomaterial-based medical device products. Then based on clinical needs, market analysis, and relevant regulations, some ideas are proposed to integrate the two different mindsets to guide applied basic research and translation of biomaterial-based products, from the material and technical perspectives. Cartilage repair substitutes are discussed here as an example. Hopefully, this will lay a strong foundation for biomaterial research and clinical translation, while reducing the amount of extra research effort and funding required due to the dissonance between innovative basic research and commercialization pipeline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.