Evidence map›Paper›PMID 34820551›Full record

ArticleBioactive materials2022

Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation.

Jie Sun, Yingkang Huang, Huan Zhao, Junjie Niu, Xuwei Ling, Can Zhu, Lin Wang, Huilin Yang, Zhilu Yang, Guoqing Pan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
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  6. Biopolymer Membranes for Osmotic Power Generation in Bionic Applications.Advanced materials (Deerfield Beach, Fla.) · 2025
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  7. Article
  8. Article
  9. Article
  10. Review
  11. Osseointegration Process ImprovingCurrent topics in medicinal chemistry · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jie SunDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai, Suzhou, Jiangsu, 215031, China.
Yingkang HuangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai, Suzhou, Jiangsu, 215031, China.
Huan ZhaoDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai, Suzhou, Jiangsu, 215031, China.
Junjie NiuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai, Suzhou, Jiangsu, 215031, China.
Xuwei LingDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai, Suzhou, Jiangsu, 215031, China.
Can ZhuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai, Suzhou, Jiangsu, 215031, China.
Lin WangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai, Suzhou, Jiangsu, 215031, China.
Huilin YangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai, Suzhou, Jiangsu, 215031, China.
Zhilu YangAffiliated Dongguan Hospital, Southern Medical University, No. 3 Wandao Road, Dongguan, Guangdong, 523059, China.
Guoqing PanInstitute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, China.
Qin ShiDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 899 Pinghai, Suzhou, Jiangsu, 215031, China.
Soochow University · CNJiangsu University · CNKey Laboratory of Guangdong Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Upon the osteoporotic condition, sluggish osteogenesis, excessive bone resorption, and chronic inflammation make the osseointegration of bioinert titanium (Ti) implants with surrounding bone tissues difficult, often lead to prosthesis loosening, bone collapse, and implant failure. In this study, we firstly designed clickable mussel-inspired peptides (DOPA-N3) and grafted them onto the surfaces of Ti materials through robust catechol-TiO

Indexed as

Bio-orthogonal reactionClickable mussel-inspired peptideImmunopolarizationOsseointegrationTitanium implant

Identifiers

PMID34820551
PMCPMC8586442
OpenAlexW3202556393

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.