Evidence map›Paper›PMID 34820453›Full record

ReviewBioMed research international2021

The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier.

Shanshan Chen, Chi Zhang, Beihui He, Ruonan He, Li Xu, Shuo Zhang

Open access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Metamorphosis and lncRNAs: A Close Relationship.Genesis (New York, N.Y. : 2000) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shanshan ChenThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.ORCID https://orcid.org/0000-0001-6433-2184
Chi ZhangThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.ORCID https://orcid.org/0000-0002-8983-206X
Beihui HeThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.ORCID https://orcid.org/0000-0001-6170-8481
Ruonan HeThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.ORCID https://orcid.org/0000-0002-4167-885X
Li XuThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.ORCID https://orcid.org/0000-0002-6750-9077
Shuo ZhangThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.ORCID https://orcid.org/0000-0003-1120-5872
Zhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

lncRNA is a transcript that is more than 200 bp in length. Currently, evidence has shown that lncRNA is of great significance in cell activity, involved in epigenetics, gene transcription, chromatin regulation, etc. The existence of an intestinal mucosal mechanical barrier hinders the invasion of pathogenic bacteria and toxins, maintaining the stability of the intestinal environment. Serious destruction or dysfunction of the mechanical barrier often leads to intestinal diseases. This review first summarizes the ability of lncRNAs to regulate the intestinal mucosal mechanical barrier. We then discussed how lncRNAs participate in various intestinal diseases by regulating the intestinal mucosal mechanical barrier. Finally, we envision its potential as a new marker for diagnosing and treating intestinal inflammatory diseases.

Indexed as

AnimalsBiomechanical PhenomenaColorectal NeoplasmsGene ExpressionGenetic MarkersHumansInflammatory Bowel DiseasesIntestinal MucosaModels, BiologicalPermeabilityReceptors, CalcitriolRNA, Long NoncodingCCAT1 long noncoding RNA, humanGenetic MarkersH19 long non-coding RNAlong noncoding RNA SPRY4-IT1, humanNEAT1 long non-coding RNA, humanPlncRNA-1, humanReceptors, CalcitriolRNA, Long NoncodingVDR protein, human

Identifiers

PMID34820453
PMCPMC8608538
OpenAlexW3212176936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.