Evidence map›Paper›PMID 34820385›Full record

ArticleFrontiers in cell and developmental biology2021

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Accelerate Functional Recovery After Spinal Cord Injury by Promoting the Phagocytosis of Macrophages to Clean Myelin Debris.

Xiaolong Sheng, Jinyun Zhao, Miao Li, Yan Xu, Yi Zhou, Jiaqi Xu, Rundong He, Hongbin Lu, Tianding Wu, Chunyue Duan and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Xiaolong ShengDepartment of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Jinyun ZhaoDepartment of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Miao LiDepartment of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Yan XuKey Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.
Yi ZhouDepartment of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Jiaqi XuDepartment of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Rundong HeDepartment of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Hongbin LuKey Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.
Tianding WuDepartment of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Chunyue DuanDepartment of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Yong CaoDepartment of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Jianzhong HuDepartment of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNSoil and Fertilizer Institute of Hunan Province · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophage phagocytosis contributes predominantly to processing central nervous system (CNS) debris and further facilitates neurological function restoration after CNS injury. The aims of this study were to evaluate the effect of bone marrow mesenchymal stem cells (BMSC)-derived exosomes (BMSC-Exos) on the phagocytic capability of macrophages to clear myelin debris and to investigate the underlying molecular mechanism during the spinal cord injury (SCI) process. This work reveals that monocyte-derived macrophages (MDMs) infiltrating into the SCI site could efficiently engulf myelin debris and process phagocytic material. However, the phagocytic ability of macrophages to clear tissue debris is compromised after SCI. The administration of BMSC-Exos as an approach for SCI treatment could rescue macrophage normal function by improving the phagocytic capability of myelin debris internalization, which is beneficial for SCI repair, as evidenced by better axon regrowth and increased hindlimb locomotor functional recovery in a rodent model. Examination of macrophage treatment with BMSC-Exos revealed that BMSC-Exos could promote the capacity of macrophages to phagocytose myelin debris

Indexed as

BMSC derived exosomesmacrophagemyelin debrisphagocytosisspinal cord injury

Identifiers

PMID34820385
PMCPMC8606563
OpenAlexW3214204667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.