Evidence map›Paper›PMID 34820371›Full record

ArticleFrontiers in cell and developmental biology2021

Francesco Manfrevola, Guillaume Martinez, Charles Coutton, Domenico Rocco, Karine Reynaud, Yves Le Vern, Pascal Froment, Linda Beauclair, Denise Aubert, Riccardo Pierantoni and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Epididymal-Born circRNA Cargo and Its Implications in Male Fertility.International journal of molecular sciences · 2025
    Review
  2. Article
  3. Article
  4. KISS1R and ANKRD31 Cooperate to Enhance Leydig Cell Gene ExpressionFrontiers in cell and developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Francesco ManfrevolaDipartimento di Medicina Sperimentale, Università degli Studi della Campania L. Vanvitelli, Naples, Italy.
Guillaume MartinezHôpital Couple-Enfant, Centre Hospitalier Universitaire de Grenoble, UM de Génétique Chromosomique, Grenoble, France.
Charles CouttonHôpital Couple-Enfant, Centre Hospitalier Universitaire de Grenoble, UM de Génétique Chromosomique, Grenoble, France.
Domenico RoccoDipartimento di Medicina Sperimentale, Università degli Studi della Campania L. Vanvitelli, Naples, Italy.
Karine ReynaudCNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, France.
Yves Le VernINRAE, Université de Tours, ISP, Nouzilly, France.
Pascal FromentCNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, France.
Linda BeauclairCNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, France.
Denise AubertUniv Lyon, ENS de Lyon, INRAE, CNRS, Institut de Génomique Fonctionnelle de Lyon, Lyon, France.
Riccardo PierantoniDipartimento di Medicina Sperimentale, Università degli Studi della Campania L. Vanvitelli, Naples, Italy.
Rosanna ChianeseDipartimento di Medicina Sperimentale, Università degli Studi della Campania L. Vanvitelli, Naples, Italy.
Florian GuillouCNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, France.
University of Campania "Luigi Vanvitelli" · ITCentre National de la Recherche Scientifique · FRInfectiologie Animale et Santé Publique · FRInserm · FRInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · FRPhysiologie de la Reproduction et des Comportements · FRUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ankyrin proteins (ANKRD) are key mediators linking membrane and sub-membranous cytoskeletal proteins. Recent findings have highlighted a new role of ANKRD31 during spermatogenesis, elucidating its involvement in meiotic recombination and male germ cell progression. Following testicular differentiation, spermatozoa (SPZ) enter into the epididymis, where they undergo several biochemical and enzymatic changes. The epididymal epithelium is characterized by cell-to-cell junctions that are able to form the blood-epididymal barrier (BEB). This intricate epithelial structure provides the optimal microenvironment needed for epididymal sperm maturation. To date, no notions have been reported regarding a putative role of ANKRD31 in correct BEB formation. In our work, we generated an

Indexed as

ankyrinsblood-epididymal-barriermale infertilityspermatogenesissperm quality

Identifiers

PMID34820371
PMCPMC8607815
OpenAlexW3214384909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.