ReviewTremor and other hyperkinetic movements (New York, N.Y.)2021
The Role of the Cerebellum in Tremor - Evidence from Neuroimaging.
Review in Tremor and other hyperkinetic movements (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI.NeuroImage. Clinical · 2023Pooled it
- Essential Tremor Suppression with a Novel Anti-Tremor Orthosis: A Randomized Crossover Trial.Movement disorders : official journal of the Movement Disorder Society · 2025Trial
- Intelligent differentiation between Parkinson's disease and essential tremor using wearable sensors and machine learning: a temporal validation study.BMC medical informatics and decision making · 2026Article
- Longitudinal Trajectories in Essential Tremor: Evidence From A Seven-Year Follow-Up of Motor and Non-Motor Symptoms.European journal of neurology · 2026Article
- Temporal Dynamics of Parkinson's Disease Tremor: Clinical and Neuroimaging Insights.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Olfactory dysfunction in essential tremor with rest tremor: a cross-sectional comparison with parkinson's disease and essential tremor.BMC neurology · 2026Article
- An Exploratory Study of Auditory Brainstem Responses and Hearing Thresholds in Essential Tremor.Medicina (Kaunas, Lithuania) · 2026Article
- Impact of PSA- versus STN-DBS on effective connectivity in Parkinson's disease - a 3.0T resting-state fMRI study.NPJ Parkinson's disease · 2026Article
- Structural brain changes in the development of essential tremor: toward early diagnosis.Frontiers in aging neuroscience · 2026Article
- Empathy and alexithymia in essential tremor.Frontiers in psychiatry · 2026Article
- Evolution and trends in tremor diagnosis and differential diagnosis-a bibliometric study.Frontiers in aging neuroscience · 2026Review
- Quercetin nanoemulsion ameliorates tremor and neuroinflammatory dysregulation: behavioral and molecular insights in a mouse model of essential tremor.Behavioral and brain functions : BBF · 2025Article
- Defining the Rhythm: Developing a New Method to Describe Tremor and Myoclonus.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Phenotypical Differentiation of Tremor Using Time Series Feature Extraction and Machine Learning.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- The Relationship between Rest Tremor and Underlying Lewy Pathology in Essential Tremor: A Clinical-Pathological Study of 201 Cases.Annals of neurology · 2025Article
- The cerebellar involvement in essential tremor: the connecting roads.Arquivos de neuro-psiquiatria · 2025Review
- Effects of subanesthetic dose of ketamine on motor and cognitive outcomes of harmaline-induced essential tremor model: a focus on Lingo-1 and inflammatory pathways.BMC neuroscience · 2025Article
- Serum glial fibrillary acidic protein is elevated in early-stage late-onset essential tremor and associated with tremor progression.Journal of neural transmission (Vienna, Austria : 1996) · 2025Observational
- Pathophysiological Role of Primary Motor Cortex in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Tremor: Clinical Frameworks, Network Dysfunction and Therapeutics.Brain sciences · 2025Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neuroimaging research has played a key role in identifying which cerebral changes are associated with tremor. Here we will focus on the cerebellum, which may drive tremor oscillations, process tremor-related afferents, modulate activity in remote brain regions, or a combination. Methods: On the 6 Results: In ET, tremor-related activity is found in motor areas of the bilateral cerebellum, and altered functional connectivity within and outside the cerebellum correlates with tremor severity. Furthermore, ET is associated with cerebellar atrophy, but also with compensatory structural changes outside the cerebellum (e.g. supplementary motor area). In PD, tremor-related cerebellar activity and increased cerebello-thalamic coupling has been found. Emerging evidence suggests that the cerebellum plays a key role in dopamine-resistant rest tremor and in postural tremor. Cerebellar structural alterations have been identified in PD, but only some relate to tremor. DT is associated with more widespread cerebral networks than other tremor types. Discussion: In ET, the cerebellum likely acts as an oscillator, potentially due to loss of inhibitory mechanisms. In contrast, in PD the cerebellum may be a modulator, which contributes to tremor oscillations by influencing the thalamo-cortical system. The precise role of the cerebellum in DT remains unclear. We recommend that future research measures tremor-related activity directly by combining electrophysiology with neuroimaging, while brain stimulation techniques may be used to establish causality. Highlights: This review of neuroimaging studies has provided convincing evidence that the cerebellum plays a key role in the pathophysiology of ET, PD tremor, and dystonic tremor syndromes. This contribution may consist of driving tremor oscillations, processing tremor-related afferents, modulating activity in remote brain regions, or all the above.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.