Evidence map›Paper›PMID 34820101›Full record

ArticleChemical science2021

Enzyme-activated near-infrared fluorogenic probe with high-efficiency intrahepatic targeting ability for visualization of drug-induced liver injury.

Yong Zhang, Xueqian Chen, Qing Yuan, Yongning Bian, Mingrui Li, Yaling Wang, Xueyun Gao, Dongdong Su

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 71 citations in OpenAlex.

  1. Review
  2. Article
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    Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yong ZhangDepartment of Chemistry and Biology, Faculty of Environment and Life Science, Beijing University of Technology Beijing 100124 P. R. China chmsudd@bjut.edu.cn gaoxy@ihep.ac.cn.
Xueqian ChenDepartment of Chemistry and Biology, Faculty of Environment and Life Science, Beijing University of Technology Beijing 100124 P. R. China chmsudd@bjut.edu.cn gaoxy@ihep.ac.cn.
Qing YuanDepartment of Chemistry and Biology, Faculty of Environment and Life Science, Beijing University of Technology Beijing 100124 P. R. China chmsudd@bjut.edu.cn gaoxy@ihep.ac.cn.
Yongning BianDepartment of Chemistry and Biology, Faculty of Environment and Life Science, Beijing University of Technology Beijing 100124 P. R. China chmsudd@bjut.edu.cn gaoxy@ihep.ac.cn.
Mingrui LiDepartment of Chemistry and Biology, Faculty of Environment and Life Science, Beijing University of Technology Beijing 100124 P. R. China chmsudd@bjut.edu.cn gaoxy@ihep.ac.cn.
Yaling WangDepartment of Chemistry and Biology, Faculty of Environment and Life Science, Beijing University of Technology Beijing 100124 P. R. China chmsudd@bjut.edu.cn gaoxy@ihep.ac.cn.
Xueyun GaoDepartment of Chemistry and Biology, Faculty of Environment and Life Science, Beijing University of Technology Beijing 100124 P. R. China chmsudd@bjut.edu.cn gaoxy@ihep.ac.cn.ORCID https://orcid.org/0000-0002-2267-9945
Dongdong SuDepartment of Chemistry and Biology, Faculty of Environment and Life Science, Beijing University of Technology Beijing 100124 P. R. China chmsudd@bjut.edu.cn gaoxy@ihep.ac.cn.ORCID https://orcid.org/0000-0002-7463-4466
Beijing University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatotoxicity is a serious problem faced by thousands of clinical drugs, and drug-induced liver injury (DILI) caused by chronic administration or overdose has become a major biosafety issue. However, the near-infrared (NIR) fluorescent probes currently used for liver injury detection still suffer from poor liver targeting ability and low sensitivity. Enzyme-activated fluorogenic probes with powerful

Identifiers

PMID34820101
PMCPMC8597858
OpenAlexW3205815913

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.