Evidence map›Paper›PMID 34820034›Full record

Trial reportCanadian respiratory journal2021

Efficacy and Safety of Ergoferon in Children from 6 Months to 6 Years Old with Acute Respiratory Viral Infections in Contemporary Outpatient Practice: A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial.

N A Geppe, B M Blokhin, O V Shamsheva, S T Abdrakhmanova, K A Alikhanova, G T Myrzabekova

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Canadian respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Analysis of General Toxicity of Ergoferon.Bulletin of experimental biology and medicine · 2023
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

N A GeppeDepartment of Childhood Diseases, Sechenov First Moscow State Medical University, Moscow 119435, Russia.ORCID 0000-0003-0547-3686
B M BlokhinDepartment of Polyclinic and Emergency Pediatrics, Pirogov Russian National Research Medical University, Moscow 117997, Russia.
O V ShamshevaChildren's Medical Center, Main Medical Department of the Presidential Administration of the Russian Federation, Moscow 109012, Russia.
S T AbdrakhmanovaDepartment of Childhood Diseases No. 3, Astana Medical University, Astana 010000, Kazakhstan.
K A AlikhanovaDepartment of General Medical Practice No. 3, Karaganda Medical University, Karaganda 100008, Kazakhstan.
G T MyrzabekovaDepartment of Pediatrics, Kazakh Medical University of Continuing Education, Almaty 050040, Kazakhstan.
Presidential Executive Office · RUAstana Medical University · KZKaraganda Medical University · KZKazakhstan Medical University · KZSechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the efficacy and safety of Ergoferon in combination with symptomatic therapy in children from 6 months to 6 years old with acute respiratory infections (ARI) in contemporary outpatient practice, an international, multicenter, double-blind, placebo-controlled, randomized, parallel-group clinical trial was performed. Derived by technological treatment of antibodies to interferon gamma, histamine, and CD4, Ergoferon was previously proved to modulate its molecular targets promoting effective antiviral protection. The data of 282 patients with oral temperature ≥38.0°C plus mild to moderate severity of flu-like nonspecific and nasal/throat/chest symptoms were included in intention-to-treat analysis (

Indexed as

Respiratory Tract InfectionsVirus DiseasesAntibodiesChildChild, PreschoolDouble-Blind MethodHumansInfantOutpatientsSARS-CoV-2Treatment OutcomeAntibodiesergoferon

Identifiers

PMID34820034
PMCPMC8608533
OpenAlexW3211552029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.