Evidence map›Paper›PMID 34819931›Full record

ArticleFrontiers in immunology2021

Indoleamine 2,3-Dioxygenase Cannot Inhibit

Dezső P Virok, Ferenc Tömösi, Anikó Keller-Pintér, Kitti Szabó, Anita Bogdanov, Szilárd Poliska, Zsolt Rázga, Bella Bruszel, Zsuzsanna Cseh, Dávid Kókai and 4 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Insights into innate immune cell evasion byFrontiers in immunology · 2024
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dezső P VirokDepartment of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Szeged, Hungary.
Ferenc TömösiDepartment of Medical Chemistry, Interdisciplinary Centre of Excellence, University of Szeged, Szeged, Hungary.
Anikó Keller-PintérDepartment of Biochemistry, University of Szeged, Szeged, Hungary.
Kitti SzabóDepartment of Biochemistry, University of Szeged, Szeged, Hungary.
Anita BogdanovDepartment of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Szeged, Hungary.
Szilárd PoliskaDepartment of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
Zsolt RázgaDepartment of Pathology, University of Szeged, Szeged, Hungary.
Bella BruszelDepartment of Medical Chemistry, Interdisciplinary Centre of Excellence, University of Szeged, Szeged, Hungary.
Zsuzsanna CsehDepartment of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Szeged, Hungary.
Dávid KókaiDepartment of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Szeged, Hungary.
Dóra ParóczaiDepartment of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Szeged, Hungary.
Valéria EndrészDepartment of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Szeged, Hungary.
Tamás JanákyDepartment of Medical Chemistry, Interdisciplinary Centre of Excellence, University of Szeged, Szeged, Hungary.
Katalin BuriánDepartment of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Szeged, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Neutrophil granulocytes are the major cells involved in Methods: Global gene expression screen was used to evaluate the effect of Results: Our results indicate that the Conclusions: IDO activity was not able to inhibit chlamydial growth in human neutrophils. Whether the IDO activity was not high enough for inhibition or other chlamydial growth-promoting host mechanisms were induced in the infected and interferon-treated neutrophils needs to be further investigated.

Indexed as

Chlamydia InfectionsChlamydia trachomatisHeLa CellsHL-60 CellsHumansIndoleamine-Pyrrole 2,3,-DioxygenaseInterferon-gammaMetabolomeNeutrophilsTranscriptomeTryptophanIDO1 protein, humanIFNG protein, humanIndoleamine-Pyrrole 2,3,-DioxygenaseInterferon-gammaTryptophanChlamydiaChlamydia trachomatisgranulocyteIDOinterferonneutrophilpolymorphonuclear (PMN)

Identifiers

PMID34819931
PMCPMC8606673

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.