Evidence map›Paper›PMID 34819850›Full record

ReviewFrontiers in aging neuroscience2021

Microglia Polarization in Alzheimer's Disease: Mechanisms and a Potential Therapeutic Target.

Qinqin Wang, Hongmei Yao, Wenyan Liu, Bailiu Ya, Hongju Cheng, Zhenkai Xing, Yili Wu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
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  6. 2-aminobutyrate mediates the impact of air pollution on blood biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Qinqin WangShandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, China.
Hongmei YaoAffiliated Hospital of Jining Medical University, Jining, China.
Wenyan LiuDepartment of Physiology, College of Basic Medicine, Jining Medical University, Jining, China.
Bailiu YaDepartment of Physiology, College of Basic Medicine, Jining Medical University, Jining, China.
Hongju ChengDepartment of Physiology, College of Basic Medicine, Jining Medical University, Jining, China.
Zhenkai XingShandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, China.
Yili WuThe Affiliated Kangning Hospital, Wenzhou Medical University, Wenzhou, China.
Jining Medical University · CNAffiliated Hospital of Jining Medical University · CNJinzhou Kangning Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation regulated by microglia is one of the important factors involved in the pathogenesis of Alzheimer's disease (AD). Activated microglia exhibited phenotypes termed as M1 and M2 phenotypes separately. M1 microglia contribute to the development of inflammation

Indexed as

Alzheimer’s diseaseM1 microgliaM2 microgliamicroglia activationneuroinflammation

Identifiers

PMID34819850
PMCPMC8606412
OpenAlexW3214462359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.