ArticleNature2021
FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.
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In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 67 citations in OpenAlex.
- The RNA-Binding Protein PARN Remodeled 3' UTR Structure Defines Poly(A)-Loading Sites to Mediate Immunoglobulin Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- DeepSAP: improved RNA-seq alignment by integrating transcriptome guidance with transformer-based splice junction scoring.Genome biology · 2026Article
- UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repair.Nucleic acids research · 2026Article
- R-loop disruption triggers irreversible topoisomerase 1-DNA cleavage complex formation during AID-dependent IgH gene diversification.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Methodological Landscape of DNA Damage Response Detection: From Conventional Assays to Future Innovations.Current issues in molecular biology · 2026Review
- B cell receptor stimulation inhibits class switch recombination through elevated DNA repair.DNA repair · 2026Article
- The role of chimeric FAM72B transcripts generated by intergenic mRNA trans-splicing in breast cancer.Functional & integrative genomics · 2025Article
- Genetic screening identifies Ube2v1 as a suppressor of immunoglobulin class switch recombination in CH12F3 cells.Molecular biology reports · 2025Article
- FAM72A promotes cervical cancer progression by regulating the PI3K pathway.Functional & integrative genomics · 2025Article
- B cell extracellular vesicles influence melanoma response to immune checkpoint therapy.Science advances · 2025Article
- MKLN1-dependent GID4/CTLH E3 ubiquitin ligase complex assemblies are required to support B-cell antibody diversification.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Spotlight onGenes · 2025Article
- FAM72A promotes UNG2 degradation and mutagenesis in human cancer cells.Scientific reports · 2025Article
- Article
- An era of immunological discoveries heralded by molecular biology.Trends in immunology · 2025Article
- Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination.Molecular cell · 2025Article
- Uridine Embedded within DNA is Repaired by Uracil DNA Glycosylase via a Mechanism Distinct from That of Ribonuclease H2.Journal of the American Chemical Society · 2025Article
- Nucleotide level mapping of uracils in murine heavy chain switch regions shows correlation between uracilation and positions of switch junctions created during class-switch recombination.NAR molecular medicine · 2025Article
- Molecular mechanisms of DNA lesion and repair during antibody somatic hypermutation.Science China. Life sciences · 2024Review
- Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 5 institutions in 4 countries.
Yuqing Feng *Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Conglei Li *Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Jessica A StewartDepartment of Chemistry, Wayne State University, Detroit, MI, USA.
Philip BarbulescuDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Noé Seija DesivoInstitut de recherches cliniques de Montréal, Montreal, Quebec, Canada.
Alejandro Álvarez-QuilónDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-9330-6823
Rossanna C PezoSunnybrook Health Sciences Center, Toronto, Ontario, Canada.
Madusha L W PereraDepartment of Chemistry, Wayne State University, Detroit, MI, USA.
Katherine ChanDonnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Amy Hin Yan TongDonnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Rukshana Mohamad-RamshanDepartment of Chemistry, Wayne State University, Detroit, MI, USA.
Maribel BerruDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Diana NakibDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-4046-2109
Gavin LiDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Gholam Ali KardarImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
James R CarlyleDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Jason MoffatDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-5663-8586
Daniel DurocherDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-3863-8635
Javier M Di NoiaInstitut de recherches cliniques de Montréal, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-2896-0321
Ashok S BhagwatDepartment of Chemistry, Wayne State University, Detroit, MI, USA.ORCID http://orcid.org/0000-0003-1188-0579
Alberto MartinDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada. alberto.martin@utoronto.ca.ORCID http://orcid.org/0000-0002-1260-7710
University of Toronto · CAWayne State University · USMontreal Clinical Research Institute · CASunnybrook Health Science Centre · CATehran University of Medical Sciences · IR
Funding
Mapping and Visualizing Uracils Created by AID/APOBEC Enzymes using UdgXR21AI144708 · NIAID · WAYNE STATE UNIVERSITY · PI BHAGWAT, ASHOK S · 2019 to 2020
$398kDevelopment of new technologies for high-sensitivity detection of a B-cell tumor marker in DNAR21CA252858 · NCI · WAYNE STATE UNIVERSITY · PI BHAGWAT, ASHOK S · 2021 to 2021
$365kNCI NIH HHS R21 CA252858NIAID NIH HHS R21 AI144708
Abstract
Activation-induced cytidine deaminase (AID) catalyses the deamination of deoxycytidines to deoxyuracils within immunoglobulin genes to induce somatic hypermutation and class-switch recombination
Indexed as
B-LymphocytesDNA GlycosylasesDNA Mismatch RepairImmunoglobulin Class SwitchingMembrane ProteinsMutationNeoplasm ProteinsSomatic Hypermutation, ImmunoglobulinAnimalsCRISPR-Cas SystemsEpistasis, GeneticFemaleHEK293 CellsHumansImmunoglobulin Switch RegionMiceCCNO protein, humanDNA GlycosylasesFAM72A protein, humanFam72a protein, mouseMembrane ProteinsMitochondrial ProteinsMSH2 protein, humanMsh2 protein, mouseMutS Homolog 2 ProteinNeoplasm Proteins
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.