ArticleNature2021
ecDNA hubs drive cooperative intermolecular oncogene expression.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 229 papers.
0numbers the graph read from it
0cells of the map it votes in
229citing papers in PubMed
18.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
229 citing papers in PubMed, 316 citations in OpenAlex.
- Circulating tumour DNA and extrachromosomal DNA in prostate and bladder cancer: biology, clinical applications and future perspectives.World journal of urology · 2026Review
- Genomic instability, postoperative recurrence and therapeutic vulnerabilities in resectable non‑small cell lung cancer (Review).Oncology reports · 2026Review
- Unraveling the lexicon of complex mutational phenomena in human cancers.Nature cancer · 2026Review
- Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer.Molecular cancer · 2026Review
- The shared evolutionary capacities of plasmids and extrachromosomal DNA.Nature reviews. Genetics · 2026Review
- Integrating molecular subtypes, genomics and functional dependencies to identify context-specific therapeutic vulnerabilities in small cell lung cancer.Biomarker research · 2026Review
- BRD4: From molecular understanding to therapeutics development.Molecular cell · 2026Review
- Genomic landscape and tumor immune microenvironment of osteosarcoma: Bridging mechanistic insights to precision therapeutics.Bone reports · 2026Review
- Extrachromosomal DNA in urothelial carcinoma: mechanisms and clinical applications.Nature reviews. Urology · 2026Review
- Origins and consequences of oncogenic 3D chromatin remodelling.Nature reviews. Cancer · 2026Review
- scAmp enables focal gene amplification analysis from single-cell data.Nature communications · 2026Article
- Plasticity of extrachromosomal DNA segregation during drug adaptation.Nature communications · 2026Article
- Phase separation of ecDNA condensates establishes in-trans contact domains that boost selective MYC regulatory interactions.Nature communications · 2026Article
- Examining the role of extrachromosomal DNA in lung cancer.Journal of the National Cancer Institute · 2026Article
- Telomere-driven replicative crisis is driven by large-scale changes in genomic architecture.Genome research · 2026Article
- MYC in Oncogenesis and Therapeutic Implications.MedComm · 2026Review
- Charting intratumor heterogeneity from bench to bedside.Nature cancer · 2026Review
- Hybrid extrachromosomal DNA in HPV-driven cancers.Journal of virology · 2026Review
- Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Exploring copy number alterations (CNAs) to gain new insight into SCLC heterogeneity.Molecular biology reports · 2026Review
169 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
34 authors at 9 institutions in 2 countries.
King L Hung *Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
Kathryn E Yost *Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
Liangqi Xie *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Quanming ShiCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
Konstantin HelmsauerDepartment of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-0773-4114
Jens LuebeckBioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4391-979X
Robert SchöpflinDevelopment and Disease Research Group, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Joshua T LangeDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-4246-6058
Rocío Chamorro GonzálezDepartment of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-5653-7259
Natasha E WeiserCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
Celine ChenDepartment of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-1579-024X
Maria E ValievaDevelopment and Disease Research Group, Max Planck Institute for Molecular Genetics, Berlin, Germany.ORCID http://orcid.org/0000-0002-4419-2839
Ivy Tsz-Lo WongChEM-H, Stanford University, Stanford, CA, USA.
Sihan WuChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-8329-7492
Siavash R DehkordiDepartment of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA.
Connor V DuffyCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
Katerina KraftCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
Jun TangChEM-H, Stanford University, Stanford, CA, USA.
Julia A BelkDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4724-6158
John C RoseCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
M Ryan CorcesCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-7465-7652
Jeffrey M GranjaCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8402-3442
Rui LiCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
Utkrisht RajkumarDepartment of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA.
Jordan FriedleinTumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Anindya BagchiTumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Ansuman T SatpathyDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5167-537X
Robert TjianDepartment of Molecular and Cell Biology, Li Ka Shing Center for Biomedical and Health Sciences, CIRM Center of Excellence, University of California, Berkeley, Berkeley, CA, USA.
Stefan MundlosDevelopment and Disease Research Group, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Vineet BafnaDepartment of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-5810-6241
Anton G HenssenDepartment of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-1534-778X
Paul S MischelChEM-H, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-4560-2211
Zhe LiuJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0000-0002-3592-3150
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA. howchang@stanford.edu.ORCID http://orcid.org/0000-0002-9459-4393
Stanford University · USUniversity of California San Diego · USHoward Hughes Medical Institute · USCharité - Universitätsmedizin Berlin · DEMax Planck Institute for Molecular Genetics · DESanford Burnham Prebys Medical Discovery Institute · USBerlin-Brandenburger Centrum für Regenerative Therapien · DEChildren's Medical Center · USGerman Cancer Research Center · DE
Funding
Special EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2014 to 2018
$15.2MU of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0MLncRNA mechanisms in cancerR35CA209919 · NCI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2016 to 2022
$6.4MComputational methods for detecting patterns of complex genomic variationR01GM114362 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Vineet Bafna · 2016 to 2026
$3.1MHigh Throughput DNA Sequencer UpgradeS10OD018220 · OD · STANFORD UNIVERSITY · PI COLLER, JOHN · 2014 to 2014
$596kComputer ClusterS10OD021763 · OD · STANFORD UNIVERSITY · PI JI, HANLEE P · 2016 to 2016
$481kTumor and Immune Cell Dynamics during Immunotherapy and Cancer ProgressionF99CA253729 · NCI · STANFORD UNIVERSITY · PI YOST, KATHRYN ELIZABETH · 2020 to 2020
$39kNCI NIH HHS F99 CA253729NCI NIH HHS R35 CA209919NHGRI NIH HHS P50 HG007735NIGMS NIH HHS R01 GM114362NIH HHS S10 OD018220NIH HHS S10 OD021763NINDS NIH HHS P30 NS047101
Abstract
Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high expression of oncogenes through gene amplification and altered gene regulation
Indexed as
NeoplasmsNuclear ProteinsAzepinesBromodomain Containing ProteinsCell Cycle ProteinsCell Line, TumorGene AmplificationGene Expression Regulation, NeoplasticHumansOncogenesTranscription FactorsAzepinesBRD4 protein, humanBromodomain Containing ProteinsCell Cycle ProteinsNuclear ProteinsTranscription Factors
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.