ArticleNature2021
IL-27 signalling promotes adipocyte thermogenesis and energy expenditure.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
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108citing papers in PubMed
14.5field-weighted citation impact, top 1% of its field
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Who cites it
108 citing papers in PubMed, 179 citations in OpenAlex.
- Bifidobacterium Breve BBr60 Improves Obesity Via the Gut Microbiota-Short-Chain Fatty Acid-IL-27/GLP-1 Axis: Evidence from a Randomized, Double-Blind, Placebo-Controlled Trial.Probiotics and antimicrobial proteins · 2026Trial
- Obesity-Associated Osteoarthritis: Mechanical-Metabolic Pathogenesis, Obesity Memory and Dual-Target Therapy.Current obesity reports · 2026Review
- Microglial IL-27 modulates depression-like behaviors induced by postnatal immune activation.Cell reports. Medicine · 2026Article
- IL-18 derived from microwave-ablated osteosarcoma facilitates antitumor response.Journal for immunotherapy of cancer · 2026Article
- Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.Current obesity reports · 2026Review
- C2orf74 orchestrates germ-Leydig crosstalk to inhibit white adipose tissue browning in male mice.Nature communications · 2026Article
- Article
- IL-27-Ucp2-FoxO3 axis mediating the polarization of alternatively activated macrophages and ameliorating inflammatory pain.The Korean journal of pain · 2026Article
- In vivo study of intravoxel incoherent motion imaging in assessing obesity-related kidney injury.BMC medical imaging · 2026Article
- USP25 deficiency suppresses diet-induced obesity via ubiquitination and degradation of PARP1 and Elovl3 downregulation.Journal of lipid research · 2026Article
- A Simplified Three-Tailed N-Alkyl Phosphoramidate Lipid Platform Enables Inguinal Adipose-Accumulated mRNA Delivery for Anti-Obesity Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Insulin Resistance and Inflammation.International journal of molecular sciences · 2026Review
- Exercise mitigates IL-27-induced muscle atrophy following myocardial infarction through anti-inflammatory mechanisms.Journal of translational medicine · 2026Article
- Article
- IL-27, a metabolic regulator secreted by astrocytes in response to GLP-1RA OHP2, modulates microglial reprogramming in Alzheimer's disease by regulating cGAS lactylation.Journal of neuroinflammation · 2026Article
- Review
- Expression and significance of IL-27 and IL-35 in orbital fat in patients with severe TAO.Diagnostic pathology · 2026Article
- ACLY Safeguards Copper Homeostasis to Sustain Brown Adipose Tissue Thermogenesis and Restrain Diet-Induced Obesity.Research (Washington, D.C.) · 2026Article
- Article
- High-intensity intermittent training promotes adipose tissue browning via the IL-27/p38 MAPK-PGC-1α signaling pathway in diet-induced obese rats.Frontiers in physiology · 2026Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 8 institutions in 2 countries.
Qian Wang *Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.ORCID http://orcid.org/0000-0003-4755-7001
Dehai Li *Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
Guangchao Cao *Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.ORCID http://orcid.org/0000-0003-2069-3396
Qiping Shi *Department of Endocrine, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Jing ZhuGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
Mingyue ZhangGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
Hao ChengKey Laboratory for the Genetics of Developmental & Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
Qiong WenGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
Hao XuDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Leqing ZhuThe Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
Hua ZhangGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
Rachel J PerryDepartment of Medicine, School of Medicine, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-0748-8064
Olga SpadaroDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Yunfan YangDepartment of Comparative Medicine, School of Medicine, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5266-7208
Shengqi HeHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, Wuhan, China.
Yong ChenHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, Wuhan, China.
Baocheng WangTsinghua Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen, China.
Guangqiang LiThe Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
Zonghua LiuGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
Caixian YangDepartment of Endocrine, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China.
Xiaoli WuSchool of Life Sciences, Tianjin University, Tianjin, China.
Libing ZhouGuangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, China.
Qinghua ZhouGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
Zhenyu JuKey Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, China.ORCID http://orcid.org/0000-0002-9525-6521
Hongyun LuGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
Yongjie XinGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China.
Xiaoyong YangDepartment of Cellular & Molecular Physiology, School of Medicine, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5315-7285
Cunchuan WangDepartment of Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Yong LiuHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, Wuhan, China.ORCID http://orcid.org/0000-0001-7771-4181
Gerald I ShulmanDepartment of Medicine, School of Medicine, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-1529-5668
Vishwa Deep DixitDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Ligong LuGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China. lu_ligong@163.com.ORCID http://orcid.org/0000-0002-0301-4454
Hengwen YangGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China. hengwenyang@jnu.edu.cn.ORCID http://orcid.org/0000-0002-6418-1985
Richard A FlavellDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA. richard.flavell@yale.edu.ORCID http://orcid.org/0000-0003-4461-0778
Zhinan YinGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, China. tzhinan@jnu.edu.cn.ORCID http://orcid.org/0000-0001-6524-8777
Jinan University · CNYale University · USWuhan University · CNFirst Affiliated Hospital of Jinan University · CNGuangzhou Medical University · CNShanghai Jiao Tong University · CNTianjin University · CNTsinghua–Berkeley Shenzhen Institute · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thermogenesis in brown and beige adipose tissue has important roles in maintaining body temperature and countering the development of metabolic disorders such as obesity and type 2 diabetes
Indexed as
Energy MetabolismThermogenesisAdipocytesAnimalsBariatric SurgeryDisease Models, AnimalFemaleHumansInsulin ResistanceInterleukin-27MaleMiceObesityp38 Mitogen-Activated Protein KinasesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaReceptors, InterleukinIl27ra protein, mouseInterleukin-27p38 Mitogen-Activated Protein KinasesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseReceptors, InterleukinUcp1 protein, mouseUncoupling Protein 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.