ArticleNature2021
The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 70 citations in OpenAlex.
- NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations.Cancer discovery · 2024Trial
- A pan-cancer analysis of the oncogenic role of KIF13A in human tumors.Discover oncology · 2025Article
- Landscape of gene fusions in hormone receptor-positive breast cancer reveals ADK fusions as drivers of progression and potential therapeutic targets.Cell discovery · 2025Article
- Detection of oncogenic fusions in colorectal cancer using a partner-agnostic next-generation sequencing approach.BMC cancer · 2025Article
- Genetic and oncogenic features of RASGRF fusions.NPJ precision oncology · 2025Article
- Advances in molecular pathology and therapy of non-small cell lung cancer.Signal transduction and targeted therapy · 2025Review
- Treatment of advanced‑stage non‑small cell lung cancer: Current progress and a glimpse into the future (Review).Molecular and clinical oncology · 2025Review
- Efficacy of EGFR tyrosine kinase inhibitors in patients with non-small cell lung cancer with EGFR exon 19 insertions: clinical-genomic, preclinical analysis through LC-SCRUM-Asia (multi-institutional genomic screening registry).Lung cancer (Amsterdam, Netherlands) · 2025Article
- Multi-omics integration identifies molecular markers and biological pathways for carcass and meat quality traits in Nellore cattle.Scientific reports · 2025Article
- Deep learning prioritizes cancer mutations that alter protein nucleocytoplasmic shuttling to drive tumorigenesis.Nature communications · 2025Article
- Long non-coding RNA CAR10 promotes angiogenesis of lung adenocarcinoma by mediating nuclear LDHA to epigenetically regulate VEGFA/C.Communications biology · 2025Article
- Novel kinase-activating genetic events in non-small cell lung carcinomas.Exploration of targeted anti-tumor therapy · 2025Article
- Successful and On-going Long-Term Disease Control (>24 Months) with Gilteritinib in anLung Cancer (Auckland, N.Z.) · 2025Article
- Hypothermic oxygenated perfusion inhibits CLIP1-mediated TIRAP ubiquitination via TFPI2 to reduce ischemia‒reperfusion injury of the fatty liver.Experimental & molecular medicine · 2024Article
- [Progress of IL-21 and Tfh Mediated Immunotherapy in Non-small Cell Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024Review
- Establishment and characterization of novel high mucus-producing lung tumoroids derived from a patient with pulmonary solid adenocarcinoma.Human cell · 2024Article
- LTK mutations responsible for resistance to lorlatinib in non-small cell lung cancer harboring CLIP1-LTK fusion.Communications biology · 2024Article
- Spindle cell neoplasms with novel LTK fusion - Expanding the spectrum of kinase fusion-positive soft tissue tumors.Genes, chromosomes & cancer · 2024Article
- Advances in Non-Small Cell Lung Cancer (NSCLC) Treatment-A Paradigm Shift in Oncology.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Lung cancer in patients who have never smoked - an emerging disease.Nature reviews. Clinical oncology · 2024Review
Corrections and comments
- Commented on by
- Commented on byThe2023
Authors and funding
38 authors at 15 institutions in 2 countries.
Hiroki Izumi *Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Shingo Matsumoto *Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Jie LiuDivision of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Kosuke TanakaDivision of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Shunta MoriDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Kumiko HayashiLSI Medience Corporation Central Laboratory, Itabashi-ku, Japan.
Shogo KumagaiDivision of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Yuji ShibataDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Takuma HayashidaDivision of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Kana WatanabeDepartment of Respiratory Medicine, Miyagi Cancer Center, Natori, Japan.
Tatsuro FukuharaDepartment of Respiratory Medicine, Miyagi Cancer Center, Natori, Japan.ORCID http://orcid.org/0000-0003-0440-470X
Takaya IkedaDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Kiyotaka YohDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Terufumi KatoDepartment of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan.
Kazumi NishinoDepartment of Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan.
Atsushi NakamuraDepartment of Pulmonary Medicine, Sendai Kousei Hospital, Sendai, Japan.
Ichiro NakachiPulmonary Division, Department of Internal Medicine, Saiseikai Utsunomiya Hospital, Utsunomiya, Japan.
Shoichi KuyamaDepartment of Respiratory Medicine, National Hospital Organization Iwakuni Clinical Center, Iwakuni, Japan.
Naoki FuruyaDivision of Respiratory Medicine, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Japan.ORCID http://orcid.org/0000-0001-7162-5946
Jun Sakakibara-KonishiFirst Department of Medicine, Hokkaido University Hospital, Sapporo, Japan.
Isamu OkamotoResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kageaki TaimaDepartment of Respiratory Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Noriyuki EbiDepartment of Respiratory Medicine, Iizuka Hospital, Iizuka, Japan.
Haruko DagaDepartment of Medical Oncology, Osaka City General Hospital, Osaka, Japan.
Akira YamasakiDivision of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan.
Masahiro KodaniDivision of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan.
Hibiki UdagawaDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Keisuke KiritaDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Yoshitaka ZenkeDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Kaname NosakiDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Eri SugiyamaDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Tetsuya SakaiDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Tokiko NakaiDepartment of Pathology and Clinical Laboratories, National Cancer Center, Kashiwa, Japan.
Genichiro IshiiDepartment of Pathology and Clinical Laboratories, National Cancer Center, Kashiwa, Japan.
Seiji NihoDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Atsushi OhtsuDepartment of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Susumu S KobayashiDivision of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan. sukobaya@east.ncc.go.jp.ORCID http://orcid.org/0000-0003-2262-4001
Koichi GotoDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan. kgoto@east.ncc.go.jp.ORCID http://orcid.org/0000-0002-3023-2510
National Cancer Center Hospital East · JPMiyagi Prefectural Hospital Organization · JPTottori University · JPAso Iizuka Hospital · JPBeth Israel Deaconess Medical Center · USHirosaki University · JPHokkaido University Hospital · JPIwakuni Medical Center · JPKanagawa Prefectural Hospital Organization · JPKyushu University · JPOsaka City General Hospital · JPOsaka International Cancer Institute · JPSaiseikai Utsunomiya hospital · JPSendai Kousei Hospital · JPSt. Marianna University School of Medicine · JP
Funding
Role of KAT5 in lung cancerR01CA240257 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KOBAYASHI, SUSUMU · 2020 to 2024
$2.0MNCI NIH HHS R01 CA240257
Abstract
Lung cancer is one of the most aggressive tumour types. Targeted therapies stratified by oncogenic drivers have substantially improved therapeutic outcomes in patients with non-small-cell lung cancer (NSCLC)
Indexed as
Adenocarcinoma of LungAminopyridinesAnimalsCarcinoma, Non-Small-Cell LungCell Line, TumorCell Transformation, NeoplasticChromosomes, Human, Pair 12Chromosomes, Human, Pair 15HumansLactamsLung NeoplasmsMiceMice, NudeMicrotubule-Associated ProteinsNeoplasm ProteinsOncogene Proteins, FusionAminopyridinescytoplasmic linker protein 170LactamslorlatinibLTK protein, humanMicrotubule-Associated ProteinsNeoplasm ProteinsOncogene Proteins, FusionPyrazolesReceptor Protein-Tyrosine Kinases
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.