ArticleNature microbiology2021
Wolbachia cifB induces cytoplasmic incompatibility in the malaria mosquito vector.
Article in Nature microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 86 citations in OpenAlex.
- Wolbachia strain wLhui induces temperature-dependent incomplete cytoplasmic incompatibility in the invasive pest Liriomyza huidobrensis with biocontrol potential.Pest management science · 2026Article
- Phenotypic divergence is driven by mobile genetic elements in a heritable insect symbiont.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Calibrating and documenting host-switching and evolution of incompatibility loci for two closely related Wolbachia clades.Genetics · 2026Article
- Temperature-sensitive cytoplasmic incompatibility across divergent Wolbachia partly reflects cifB transcription, not endosymbiont density.Molecular biology and evolution · 2026Article
- Identification of twomBio · 2026Article
- Temperature-sensitive cytoplasmic incompatibility across divergentbioRxiv : the preprint server for biology · 2026Article
- Counting cytoplasmic incompatibility factor mRNA using digital droplet PCR.Microbiology spectrum · 2026Article
- Calibrating and documenting host-switching and evolution of incompatibility loci for two closely relatedbioRxiv : the preprint server for biology · 2026Article
- AISME communications · 2026Article
- Deubiquitylases and nucleases in bacterial symbiont-induced cytoplasmic incompatibility.Biochemical Society transactions · 2025Review
- Wolbachia-mediated reproductive manipulation in rice planthoppers.Crop health · 2025Review
- Both maternal and paternal genotypes modulate Wolbachia-induced cytoplasmic incompatibility in graham bean beetles.Heredity · 2025Article
- Reciprocal Host-Evolutionary applications · 2025Article
- Suppression of cytoplasmic incompatibility in the leaf-mining flyRoyal Society open science · 2025Article
- ExploitingPathogens (Basel, Switzerland) · 2025Review
- Article
- Gene drive-based population suppression in the malaria vector Anopheles stephensi.Nature communications · 2025Article
- Gene drives: an alternative approach to malaria control?Gene therapy · 2025Review
- No Evidence forInsects · 2024Article
- Loss-of-function in testis-specific serine/threonine protein kinase triggers male infertility in an invasive moth.Communications biology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Wolbachia, a maternally inherited intracellular bacterial species, can manipulate host insect reproduction by cytoplasmic incompatibility (CI), which results in embryo lethality in crosses between infected males and uninfected females. CI is encoded by two prophage genes, cifA and cifB. Wolbachia, coupled with the sterile insect technique, has been used in field trials to control populations of the dengue vector Aedes albopictus, but CI-inducing strains are not known to infect the malaria vector Anopheles gambiae. Here we show that cifA and cifB can induce conditional sterility in the malaria vector An. gambiae. We used transgenic expression of these Wolbachia-derived genes in the An. gambiae germline to show that cifB is sufficient to cause embryonic lethality and that cifB-induced sterility is rescued by cifA expression in females. When we co-expressed cifA and cifB in male mosquitoes, the CI phenotype was attenuated. In female mosquitoes, cifB impaired fertility, which was overcome by co-expression of cifA. Our findings pave the way towards using CI to control malaria mosquito vectors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.