Evidence map›Paper›PMID 34819636›Full record

SynthesisMolecular psychiatry2022

Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale.

James S W Hong, Lauren Z Atkinson, Noura Al-Juffali, Amine Awad, John R Geddes, Elizabeth M Tunbridge, Paul J Harrison, Andrea Cipriani

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.

  1. Pooled it
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  13. α2δ-1-NMDAR1 complex in the hypothalamic paraventricular nucleus mediates anxiety-induced sympathetic hyperactivity.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

James S W Hong *Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.
Lauren Z Atkinson *Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.ORCID http://orcid.org/0000-0001-5549-8721
Noura Al-JuffaliDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.ORCID http://orcid.org/0000-0001-9190-6729
Amine AwadDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.
John R GeddesDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.
Elizabeth M TunbridgeDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.ORCID http://orcid.org/0000-0002-2966-2281
Paul J Harrison *Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK. paul.harrison@psych.ox.ac.uk.ORCID http://orcid.org/0000-0002-6719-1126
Andrea Cipriani *Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK. andrea.cipriani@psych.ox.ac.uk.ORCID http://orcid.org/0000-0001-5179-8321
Oxford Health NHS Foundation Trust · GBWarneford Hospital · GB

Funding

Department of Health IS-BRC-1215-20005Department of Health RP-2017-08-ST2-006
6 · The paper itself

Abstract

The gabapentinoids, gabapentin, and pregabalin, target the α

Indexed as

Bipolar DisorderCyclohexanecarboxylic AcidsSleep Initiation and Maintenance DisordersAminesAnxietyCalcium ChannelsGabapentingamma-Aminobutyric AcidHumansPregabalinRandomized Controlled Trials as TopicAminesCalcium ChannelsCyclohexanecarboxylic AcidsGabapentingamma-Aminobutyric AcidPregabalin

Identifiers

PMID34819636
PMCPMC9095464
OpenAlexW3208254278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.