ArticleScientific reports2021
Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
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- LED lighting (350-650nm) undermines human visual performance unless supplemented by wider spectra (400-1500nm+) like daylight.Scientific reports · 2026Article
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- RLRL Therapeutic Feasibility and Potential Mechanism on Myopia.International journal of molecular sciences · 2025Review
- Longer wavelengths in sunlight pass through the human body and have a systemic impact which improves vision.Scientific reports · 2025Article
- Design of a smart contact lens for controlled retinal lighting in red light therapy.Biomedical optics express · 2025Article
- Impact of short wavelength light exposure on body weight, mobility, anxiety like behaviour and cytokine expression.Scientific reports · 2025Article
- Synthesis and Optical Properties of CdSeTe/CdZnS/ZnS Core/Shell Nanorods.Nanomaterials (Basel, Switzerland) · 2024Article
- Photobiomodulation therapy for congenital color vision deficiency: results of a preliminary randomized clinical trial.Frontiers in medicine · 2024Article
- Use ofAging cell · 2023Article
- Mitochondrial decline in the ageing old world primate retina: Little evidence for difference between the centre and periphery.PloS one · 2023Article
- Systemic glucose levels are modulated by specific wavelengths in the solar light spectrum that shift mitochondrial metabolism.PloS one · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mitochondrial decline in ageing robs cells of ATP. However, animal studies show that long wavelength exposure (650-900 nm) over weeks partially restores ATP and improves function. The likely mechanism is via long wavelengths reducing nanoscopic interfacial water viscosity around ATP rota pumps, improving their efficiency. Recently, repeated 670 nm exposures have been used on the aged human retina, which has high-energy demands and significant mitochondrial and functional decline, to improve vision. We show here that single 3 min 670 nm exposures, at much lower energies than previously used, are sufficient to significantly improve for 1 week cone mediated colour contrast thresholds (detection) in ageing populations (37-70 years) to levels associated with younger subjects. But light needs to be delivered at specific times. In environments with artificial lighting humans are rarely dark-adapted, hence cone function becomes critical. This intervention, demonstrated to improve aged mitochondrial function can be applied to enhance colour vision in old age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.