ArticleCommunications biology2021
An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Conned by the enemy: the entomopathogenic fungus Metarhizium anisopliae lures and kills Drosophila suzukii.Pest management science · 2026Article
- Gestational and Lactational Atrazine Exposure Potentially Mediates Behavioral and Dopaminergic Alterations in Rat Offspring: Insights into Nurr1-Related ceRNA Regulation.International journal of molecular sciences · 2026Article
- Genome-wide association studies identify new candidate genes and tissues underlying resistance to a natural toxin in drosophilids.G3 (Bethesda, Md.) · 2026Article
- Specific Hepatorenal Toxicity and Cross-Species Susceptibility of Eight Representative Pesticides.Toxics · 2025Article
- Gut microbiota-mediated lipid accumulation as a driver of evolutionary adaptation to blue light toxicity in Drosophila.Communications biology · 2025Article
- Human sperm as an in vitro toxicity model: a versatile tool for assessing the risk of environmental contaminants.Archives of toxicology · 2025Article
- Lactic acid bacteria modulate the CncC pathway to enhance resistance to β-cypermethrin in the oriental fruit fly.The ISME journal · 2024Article
- Exploring Metabolic and Gut Microbiome Responses to Paraquat Administration in Male Wistar Rats: Implications for Oxidative Stress.Antioxidants (Basel, Switzerland) · 2024Article
- Defining the environmental determinants of dysbiosis at scale with zebrafish.Current opinion in toxicology · 2023Article
- Pesticide exposure and the microbiota-gut-brain axis.The ISME journal · 2023Review
- The Role of Insect Symbiotic Bacteria in Metabolizing Phytochemicals and Agrochemicals.Insects · 2022Review
- Gender-related differences in the effects ofFrontiers in veterinary science · 2022Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 3 countries.
Funding
Abstract
The gut microbiome produces vitamins, nutrients, and neurotransmitters, and helps to modulate the host immune system-and also plays a major role in the metabolism of many exogenous compounds, including drugs and chemical toxicants. However, the extent to which specific microbial species or communities modulate hazard upon exposure to chemicals remains largely opaque. Focusing on the effects of collateral dietary exposure to the widely used herbicide atrazine, we applied integrated omics and phenotypic screening to assess the role of the gut microbiome in modulating host resilience in Drosophila melanogaster. Transcriptional and metabolic responses to these compounds are sex-specific and depend strongly on the presence of the commensal microbiome. Sequencing the genomes of all abundant microbes in the fly gut revealed an enzymatic pathway responsible for atrazine detoxification unique to Acetobacter tropicalis. We find that Acetobacter tropicalis alone, in gnotobiotic animals, is sufficient to rescue increased atrazine toxicity to wild-type, conventionally reared levels. This work points toward the derivation of biotic strategies to improve host resilience to environmental chemical exposures, and illustrates the power of integrative omics to identify pathways responsible for adverse health outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.