Evidence map›Paper›PMID 34819514›Full record

ArticleScientific reports2021

Correlates of neutralizing/SARS-CoV-2-S1-binding antibody response with adverse effects and immune kinetics in BNT162b2-vaccinated individuals.

Kenji Maeda, Masayuki Amano, Yukari Uemura, Kiyoto Tsuchiya, Tomoko Matsushima, Kenta Noda, Yosuke Shimizu, Asuka Fujiwara, Yuki Takamatsu, Yasuko Ichikawa and 12 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

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  17. Neutralizing antibodies after three doses of the BNT162b2 vaccine, breakthrough infection, and symptoms during the Omicron-predominant wave.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 2 countries.

Kenji MaedaDepartment of Refractory Viral Infections, National Center for Global Health and Medicine (NCGM) Research Institute, Tokyo, Japan. kmaeda@ri.ncgm.go.jp.
Masayuki AmanoDepartment of Clinical Sciences, Kumamoto University Hospital, Kumamoto, Japan.
Yukari UemuraCenter of Clinical Sciences, NCGM, Tokyo, Japan.
Kiyoto TsuchiyaAIDS Clinical Center, NCGM, Tokyo, Japan.
Tomoko MatsushimaSysmex Corporation, Hyogo, Japan.
Kenta NodaSysmex Corporation, Hyogo, Japan.
Yosuke ShimizuCenter of Clinical Sciences, NCGM, Tokyo, Japan.
Asuka FujiwaraDepartment of Refractory Viral Infections, National Center for Global Health and Medicine (NCGM) Research Institute, Tokyo, Japan.
Yuki TakamatsuDepartment of Refractory Viral Infections, National Center for Global Health and Medicine (NCGM) Research Institute, Tokyo, Japan.
Yasuko IchikawaJCHO Kumamoto General Hospital, Kumamoto, Japan.
Hidehiro NishimuraJCHO Kumamoto General Hospital, Kumamoto, Japan.
Mari KinoshitaJCHO Kumamoto General Hospital, Kumamoto, Japan.
Shota MatsumotoJCHO Kumamoto General Hospital, Kumamoto, Japan.
Hiroyuki GatanagaAIDS Clinical Center, NCGM, Tokyo, Japan.
Kazuhisa YoshimuraTokyo Metropolitan Institute for Public Health, Tokyo, Japan.
Shin-Ichi OkaAIDS Clinical Center, NCGM, Tokyo, Japan.
Ayako MikamiCenter of Clinical Sciences, NCGM, Tokyo, Japan.
Wataru SugiuraCenter of Clinical Sciences, NCGM, Tokyo, Japan.
Toshiyuki SatoSysmex Corporation, Hyogo, Japan.
Tomokazu YoshidaSysmex Corporation, Hyogo, Japan.
Shinya ShimadaJCHO Kumamoto General Hospital, Kumamoto, Japan.
Hiroaki MitsuyaDepartment of Refractory Viral Infections, National Center for Global Health and Medicine (NCGM) Research Institute, Tokyo, Japan. hmitsuya@hosp.ncgm.go.jp.
National Center for Global Health and Medicine · JPKumamoto Medical Center · JPSysmex (Japan) · JPKumamoto University Hospital · JPNational Institutes of Health · USTokyo Metropolitan Institute of Public Health · JP

Funding

Japan Agency for Medical Research and Development JP20fk0108160Japan Agency for Medical Research and Development JP20fk0108502Ministry of Health, Labor and Welfare, Japan JPMH20HA1006
6 · The paper itself

Abstract

While mRNA vaccines against SARS-CoV-2 are exceedingly effective in preventing symptomatic infection, their immune response features remain to be clarified. In the present prospective study, 225 healthy individuals in Japan, who received two BNT162b2 doses, were enrolled. Correlates of BNT162b2-elicited SARS-CoV-2-neutralizing activity (50% neutralization titer: NT

Indexed as

AdultAgedAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineCOVID-19COVID-19 VaccinesDrug-Related Side Effects and Adverse ReactionsFemaleHumansImmunogenicity, VaccineImmunologic TestsJapanKineticsMaleMiddle AgedAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineCOVID-19 Vaccines

Identifiers

PMID34819514
PMCPMC8613264
OpenAlexW3215434655

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.