ArticleNature communications2021
Theory of branching morphogenesis by local interactions and global guidance.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
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- TheProceedings of the National Academy of Sciences of the United States of America · 2024Article
- A biomimetic branching signal-passing tile assembly model with dynamic growth and disassembly.Journal of the Royal Society, Interface · 2024Article
- Multilevel neurium-mimetic individualized graft via additive manufacturing for efficient tissue repair.Nature communications · 2024Article
- Mechanism of branching morphogenesis inspired by diatom silica formation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Long-term day-by-day tracking of microvascular networks sprouting in fibrin gels: From detailed morphological analyses to general growth rules.APL bioengineering · 2024Article
- Fourteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer.Journal of mammary gland biology and neoplasia · 2023Article
- Self-organized and directed branching results in optimal coverage in developing dermal lymphatic networks.Nature communications · 2023Article
- Models of Purkinje cell dendritic tree selection during early cerebellar development.PLoS computational biology · 2023Article
- Inflationary theory of branching morphogenesis in the mouse salivary gland.Nature communications · 2023Article
- Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures.Nature communications · 2023Article
- Brain-wide dendrites in a near-optimal performance of dynamic range and information transmission.Scientific reports · 2023Article
- Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids.Nature communications · 2022Article
- Dynamic instability of dendrite tips generates the highly branched morphologies of sensory neurons.Science advances · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Branching morphogenesis governs the formation of many organs such as lung, kidney, and the neurovascular system. Many studies have explored system-specific molecular and cellular regulatory mechanisms, as well as self-organizing rules underlying branching morphogenesis. However, in addition to local cues, branched tissue growth can also be influenced by global guidance. Here, we develop a theoretical framework for a stochastic self-organized branching process in the presence of external cues. Combining analytical theory with numerical simulations, we predict differential signatures of global vs. local regulatory mechanisms on the branching pattern, such as angle distributions, domain size, and space-filling efficiency. We find that branch alignment follows a generic scaling law determined by the strength of global guidance, while local interactions influence the tissue density but not its overall territory. Finally, using zebrafish innervation as a model system, we test these key features of the model experimentally. Our work thus provides quantitative predictions to disentangle the role of different types of cues in shaping branched structures across scales.
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