Evidence map›Paper›PMID 34819392›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

CD8

Karen B Whittington, Amanda Prislovsky, Jacob Beaty, Lorraine Albritton, Marko Radic, Edward F Rosloniec

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
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  8. Article
  9. CAR T Cell Therapy for Rheumatoid Arthritis.Clinical reviews in allergy & immunology · 2025
    Review
  10. Review
  11. Treating connective tissue disease-associated interstitial lung disease - think outside the box: a perspective.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Karen B WhittingtonVeterans Affairs Medical Center, Memphis TN.
Amanda PrislovskyVeterans Affairs Medical Center, Memphis TN.
Jacob BeatyDepartment of Medicine, University of Tennessee Health Science Center, Memphis TN.ORCID 0000-0002-6008-9989
Lorraine AlbrittonDepartment of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis TN; and.
Marko RadicDepartment of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis TN; and.ORCID 0000-0002-8004-282X
Edward F RosloniecVeterans Affairs Medical Center, Memphis TN; erosloniec@uthsc.edu.ORCID 0000-0001-6225-5867
University of Tennessee Health Science Center · USVeterans Health Administration · US

Funding

Chimeric antigen receptor (CAR) therapy for autoimmune arthritisR21AR071633 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI ROSLONIEC, EDWARD F · 2017 to 2018
$305k
NIAMS NIH HHS R21 AR071633
6 · The paper itself

Abstract

Ag-specific immunotherapy is a long-term goal for the treatment of autoimmune diseases; however developing a means of therapeutically targeting autoimmune T cells in an Ag-specific manner has been difficult. Through the engineering of an HLA-DR1 chimeric Ag receptor (CAR), we have produced CD8

Indexed as

AnimalsArthritis, ExperimentalArthritis, RheumatoidAutoimmune DiseasesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCytotoxicity, ImmunologicDisease Models, AnimalGenetic EngineeringHLA-DR1 AntigenHumansImmunotherapy, AdoptiveMiceMice, Inbred C57BLMice, TransgenicHLA-DR1 AntigenReceptors, Chimeric Antigen

Identifiers

PMID34819392
PMCPMC8702470
OpenAlexW3216510602

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.