Evidence map›Paper›PMID 34819365›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Temporal order of signal propagation within and across intrinsic brain networks.

Mike J Veit, Aaron Kucyi, Wenhan Hu, Chao Zhang, Baotian Zhao, Zhihao Guo, Bowen Yang, Clara Sava-Segal, Claire Perry, Jianguo Zhang and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. Macroscale Traveling Waves Evoked by Single-Pulse Stimulation of the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  17. Article
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  20. Cross-regional coordination of activity in the human brain during autobiographical self-referential processing.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mike J VeitDepartment of Neurology & Neurological Sciences, Stanford University, Stanford, CA 94305.ORCID 0000-0002-0924-2108
Aaron KucyiDepartment of Psychology, Northeastern University, Boston, MA 02115.ORCID 0000-0001-6707-0028
Wenhan HuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.ORCID 0000-0002-4068-9928
Chao ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.ORCID 0000-0002-9989-6462
Baotian ZhaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.ORCID 0000-0003-0920-6825
Zhihao GuoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.ORCID 0000-0002-4713-1337
Bowen YangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.ORCID 0000-0001-5218-7805
Clara Sava-SegalDepartment of Neurology & Neurological Sciences, Stanford University, Stanford, CA 94305.ORCID 0000-0002-3010-3858
Claire PerryDepartment of Neurology & Neurological Sciences, Stanford University, Stanford, CA 94305.ORCID 0000-0002-9324-0518
Jianguo ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.ORCID 0000-0002-0009-0574
Kai ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; zhangkai62035@sina.com jparvizi@stanford.edu.ORCID 0000-0003-4237-3115
Josef ParviziDepartment of Neurology & Neurological Sciences, Stanford University, Stanford, CA 94305; zhangkai62035@sina.com jparvizi@stanford.edu.ORCID 0000-0001-8520-7948

Funding

Experimental Study of Goal-Directed Behavior and Memory During Temporal Lobe Epileptic ActivityR21NS113024 · NINDS · STANFORD UNIVERSITY · PI PARVIZI, JOSEF · 2021 to 2022
$433k
CIHRNINDS NIH HHS R21 NS113024
6 · The paper itself

Abstract

We studied the temporal dynamics of activity within and across functional MRI (fMRI)-derived nodes of intrinsic resting-state networks of the human brain using intracranial electroencephalography (iEEG) and repeated single-pulse electrical stimulation (SPES) in neurosurgical subjects implanted with intracranial electrodes. We stimulated and recorded from 2,133 and 2,372 sites, respectively, in 29 subjects. We found that N1 and N2 segments of the evoked responses are associated with intra- and internetwork communications, respectively. In a separate cognitive experiment, evoked electrophysiological responses to visual target stimuli occurred with less temporal separation across pairs of electrodes that were located within the same fMRI-defined resting-state networks compared with those located across different resting-state networks. Our results suggest intranetwork prior to internetwork information processing at the subsecond timescale.

Indexed as

AdultBrainBrain MappingCerebral CortexCognitionElectric StimulationElectrocorticographyElectroencephalographyFemaleHumansMagnetic Resonance ImagingMaleNerve NetSpatio-Temporal AnalysisCCEPevent related potentialsgradual-onset continuous performance taskhumanintracranial EEG

Identifiers

PMID34819365
PMCPMC8640784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.