ArticleGenes & development2021
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer.
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Article in Genes & development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- Different modes of engagement with the nucleosome acidic patch yield distinct functional outcomes.Nucleic acids research · 2026Article
- Proteome-wide Ubiquitinome Profiling Reveals Substrate-specific Dynamics Within the USP7 Network.Molecular & cellular proteomics : MCP · 2026Article
- Tandem bromodomains of BRD4 cooperatively read poly-acetylated nucleosomes to enhance chromatin engagement and regulate breast cancer phenotypes.bioRxiv : the preprint server for biology · 2026Article
- PHIP suppresses NuRD to enable the growth of SWI/SNF-mutant cancers.Nature communications · 2026Article
- Direct Readout of Multivalent Chromatin Reader-Nucleosome Interactions by Nucleosome Mass Spectrometry.ACS central science · 2026Article
- Different modes of engagement with the nucleosome acidic patch yield distinct functional outcomes.bioRxiv : the preprint server for biology · 2026Article
- RepID promotes metastatic potential in osteosarcoma through regulation of the PRC1-GATA6 axis.Animal cells and systems · 2026Article
- Novel Insights: A Novel PHIP Variant in a Family with Severe Early-Onset Obesity.Hormone research in paediatrics · 2026Article
- The BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylation.Nucleic acids research · 2025Article
- Nucleosome context regulates chromatin reader preference.Nucleic acids research · 2025Article
- A needed nomenclature for nucleosomes.Molecular cell · 2025Review
- Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage.Nature communications · 2025Article
- Tumors and their microenvironments: Learning from pediatric brain pathologies.Biochimica et biophysica acta. Reviews on cancer · 2025Review
- RepID depletion enhances TWS119-induced erythropoiesis through chromatin reprogramming and transcription factor recruitment.Genes & genomics · 2025Article
- Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1.Genes & development · 2025Article
- Evolutionary origins and functional diversification of Auxin Response Factors.Nature communications · 2024Article
- Single-electron transfer between sulfonium and tryptophan enables site-selective photo crosslinking of methyllysine reader proteins.Nature chemistry · 2024Article
- The Relevance of Reperfusion Stroke Therapy for miR-9-3p and miR-9-5p Expression in Acute Stroke-A Preliminary Study.International journal of molecular sciences · 2024Article
- Article
- BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 1 country.
Marc A J MorganSimpson Querrey Center for Epigenetics, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Irina K PopovaEpiCypher, Inc., Durham, North Carolina 27709, USA.
Anup VaidyaEpiCypher, Inc., Durham, North Carolina 27709, USA.
Jonathan M BurgEpiCypher, Inc., Durham, North Carolina 27709, USA.
Matthew R MarundeEpiCypher, Inc., Durham, North Carolina 27709, USA.
Emily J RendlemanSimpson Querrey Center for Epigenetics, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Zachary J DumarSimpson Querrey Center for Epigenetics, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Rachel WatsonEpiCypher, Inc., Durham, North Carolina 27709, USA.
Matthew J MeinersEpiCypher, Inc., Durham, North Carolina 27709, USA.
Sarah A HowardEpiCypher, Inc., Durham, North Carolina 27709, USA.
Natalia KhalatyanDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Robert M VaughanDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, Minnesota 49503, USA.
Scott B RothbartDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, Minnesota 49503, USA.
Michael-C KeoghEpiCypher, Inc., Durham, North Carolina 27709, USA.ORCID 0000-0002-2219-8623
Ali ShilatifardSimpson Querrey Center for Epigenetics, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
EpiCypher (United States) · USNorthwestern University · USVan Andel Institute · US
Funding
Mutations of Chromatin and its Modifying Machineries in MalignanciesR35CA197569 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ali Shilatifard · 2015 to 2026
$10.7MMolecular mechanisms of chromatin and epigenetic regulationR35GM124736 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI ROTHBART, SCOTT · 2017 to 2021
$2.4MA novel protein engineering tool for rapid manufacturing of designer nucleosomesR44CA214076 · NCI · EPICYPHER, INC. · PI KEOGH, MICHAEL-CHRISTOPHER · 2018 to 2019
$2.0MHigh-throughput methyltransferase assays using recombinant nucleosome substratesR44GM117683 · NIGMS · EPICYPHER, INC. · PI SUN, ZU-WEN · 2018 to 2019
$1.7MBarcoded nucleosomes for analyzing combinatorial epigenetic regulatorsR44GM116584 · NIGMS · EPICYPHER, INC. · PI SUN, ZU-WEN · 2017 to 2018
$1.6MCharacterizing genetic modifiers in tumor burden of Tuberous Sclerosis ComplexK00CA245821 · NCI · MICHIGAN STATE UNIVERSITY · PI VAUGHAN, ROBERT MARK · 2021 to 2024
$374kDNA methylation regulation through the UHRF1 oncoproteinF99CA245821 · NCI · VAN ANDEL INSTITUTE GRADUATE SCHOOL · PI VAUGHAN, ROBERT MARK · 2019 to 2020
$90kNCI NIH HHS F99 CA245821NCI NIH HHS K00 CA245821NCI NIH HHS R35 CA197569NCI NIH HHS R44 CA214076NIGMS NIH HHS R35 GM124736NIGMS NIH HHS R44 GM116584NIGMS NIH HHS R44 GM117683
Abstract
Mutations in the
Indexed as
NeoplasmsNeurodevelopmental DisordersBromodomain Containing ProteinsChromatinHistonesHumansMembrane ProteinsNucleosomesProto-Oncogene ProteinsBromodomain Containing ProteinsChromatinHistonesMembrane ProteinsNucleosomesProto-Oncogene ProteinsWDR11 protein, humanchromatinhistoneneurodevelopmental disorderneuroepigenetics
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What OpenQuestion holds
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LicenceCC BY-NC
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.