Evidence map›Paper›PMID 34819308›Full record

ArticleCancer immunology research2022

C3aR Signaling Inhibits NK-cell Infiltration into the Tumor Microenvironment in Mouse Models.

Saravanan Nandagopal, Caiyun G Li, Yu Xu, Quaovi H Sodji, Edward E Graves, Amato J Giaccia

Open access · bronzeAbstract read
In one paragraph

Article in Cancer immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Complement system in cancer: friend or foe of immunotherapy.Journal for immunotherapy of cancer · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Tumor-educated cells in tumor microenvironment: Key drivers of immunotherapy resistance.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
    Article
  9. Rendering NK Cells Antigen-Specific for the Therapy of Solid Tumours.International journal of molecular sciences · 2025
    Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. CD16American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Saravanan NandagopalDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.ORCID 0000-0002-1787-3356
Caiyun G LiDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Yu XuDepartment of Bioengineering, Stanford, California.
Quaovi H SodjiDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Edward E GravesDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Amato J GiacciaDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California. amato.giaccia@oncology.ox.ac.uk.ORCID 0000-0002-1940-2750
Stanford Medicine · USBioengineering Center · RUCRUK/MRC Oxford Institute for Radiation Oncology · GB

Funding

TUMOR HYPOXIA--MOLECULAR STUDIES &CLINICAL EXPLOITATIONP01CA067166 · NCI · STANFORD UNIVERSITY · PI LE, QUYNH-THU XUAN · 1996 to 2017
$25.5M
The Impact of Mitochondrial Repression and Lipid Accumulation by HIF on Tumor GrowthR35CA197713 · NCI · STANFORD UNIVERSITY · PI GIACCIA, AMATO J. · 2015 to 2021
$5.3M
Preclinical Testing of a Novel Therapy Targeting AXL in Advanced Kidney CancerR01CA198291 · NCI · STANFORD UNIVERSITY · PI RANKIN, ERINN B · 2016 to 2020
$2.4M
Radiation-Induced Tumor Cell MigrationR01CA197136 · NCI · STANFORD UNIVERSITY · PI GRAVES, EDWARD E. · 2015 to 2019
$1.9M
Nikon A1Rsi resonant spectral confocal microscopeS10OD010580 · OD · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2013 to 2013
$377k
Cancer Research UK 28736Medical Research Council MC_UU_00001/8NCI NIH HHS P01 CA067166NCI NIH HHS R01 CA197136NCI NIH HHS R01 CA198291NCI NIH HHS R35 CA197713NIH HHS S10 OD010580
6 · The paper itself

Abstract

Many solid tumors have low levels of cytotoxic CD56

Indexed as

Killer Cells, NaturalNeoplasmsReceptors, ComplementTumor MicroenvironmentAnimalsDisease Models, AnimalLymphocyte Function-Associated Antigen-1MiceSignal Transductioncomplement C3a receptorLymphocyte Function-Associated Antigen-1Receptors, Complement

Identifiers

PMID34819308
PMCPMC9351714
OpenAlexW3215521287

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.