Evidence map›Paper›PMID 34818878›Full record

ArticleEuropean journal of translational myology2021

Preliminary results of effect of barley (<em>Hordeum vulgare L.</em>) extract on liver, pancreas, kidneys and cardiac tissues in streptozotocin induced diabetic rats.

Mohsen Naseri, Zahra Khalaj Sereshki, Behnaz Ghavami, Bagher Minaii Zangii, Mohammad Kamalinejad, Parvaneh Mohseni Moghaddam, Majid Asghari, Seyed Abbas Hashemi Nejad, Fatemeh Emadi, Farzaneh Ghaffari

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of translational myology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Mohsen NaseriTraditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran; Department of Traditional Persian Medicine, School of Medicine, Shahed University, Tehran, Iran; Hikmat, Islamic and Traditional Medicine Department, The Academy of Medical Sciences, Tehran. naseri@shahed.ac.ir.
Zahra Khalaj SereshkiDepartment of Gynecology, School of Medicine, Yas Hospital, Tehran University of Medical Sciences, Tehran. dr.zahrakhalaj@gmail.com.
Behnaz GhavamiDepartment of Gynecology, School of Medicine, Arash Hospital, Tehran University of Medical Sciences, Tehran. Behnaz.ghavami@gmail.com.
Bagher Minaii ZangiiDepartment of Histology, School of Medicine, Tehran University of Medical Sciences, Tehran. minaezb@sina.tums.ac.ir.
Mohammad KamalinejadSchool of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran. mkamalinejad@yahoo.com.
Parvaneh Mohseni MoghaddamDepartment of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. p.mohseni@iautmu.tums.ac.ir.
Majid AsghariSchool of Persian Medicine, Qom University of Medical Sciences, Qom. asghari.rall@gmail.com.
Seyed Abbas Hashemi NejadTraditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran; Department of Traditional Persian Medicine, School of Medicine, Shahed University, Tehran. abbas.hasheminejad@shahed.ac.ir.
Fatemeh EmadiTraditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran; Department of Traditional Persian Medicine, School of Medicine, Shahed University, Tehran. fatemeh12emadi@yahoo.com.
Farzaneh GhaffariSchool of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran. f_ghaffari@sbmu.ac.ir.
Tehran University of Medical Sciences · IRShahed University · IRShahid Beheshti University of Medical Sciences · IRIranian Academy of Medical Sciences · IRIslamic Azad University Medical Branch of Tehran · IRQom University of Medical Science and Health Services · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) and its complications impose a significant burden on patients and the health care system. In the Traditional Persian Medicine (TPM), barley is recommended for treatment of DM. This study sought to assess the effect of barley seed aqueous extract on hepatic, pancreatic, renal and cardiac tissues in normal (non-diabetic) and Streptozotocin-induced diabetic rats. Twenty-one male Wistar rats were randomly divided into diabetic and non-diabetic groups. Diabetes was induced by single intraperitoneal injection of Streptozotocin. After one week, the diabetic and non-diabetic groups were randomly divided into control and barley seed extract subgroups namely N group (non-diabetic control rats), S group (seed extract treated non-diabetic rats), D group (diabetic control rats) and DS group (seed extract treated diabetic rats). After 6 weeks, all rats were sacrificed for histopathological analysis and specimens were stained routinely for histological studies. The abnormal histological signs significantly decreased in the DS group compared to D group. Also, protective effects of barley seed extract against histopathological changes were seen in S group compared to N group.These findings suggest that barley seed extract exerts a protective effect on different tissues in diabetes.

Identifiers

PMID34818878
PMCPMC8992669
OpenAlexW3217175555

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.