Evidence map›Paper›PMID 34818566›Full record

Observational studyJournal of cardiac failure2022

Prescriptions for Potentially Inappropriate Medications from the Beers Criteria Among Older Adults Hospitalized for Heart Failure.

Diana Jaber, Fabian Vargas, Linh Nguyen, Joanna Ringel, Kate Zarzuela, Mahad Musse, Min Ji Kwak, Emily B Levitan, Mathew S Maurer, Mark S Lachs and 2 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cardiac failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Diana JaberSchool of Medicine & Health Sciences, George Washington University, Washington, DC.
Fabian VargasDepartment of Medicine, Weill Cornell Medicine, New York, New York.
Linh NguyenSchool of Medicine, University of Colorado, Aurora, Colorado.
Joanna RingelDepartment of Medicine, Weill Cornell Medicine, New York, New York.
Kate ZarzuelaDepartment of Medicine, Weill Cornell Medicine, New York, New York.
Mahad MusseDepartment of Medicine, Weill Cornell Medicine, New York, New York.
Min Ji KwakDepartment of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, Texas.
Emily B LevitanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
Mathew S MaurerDepartment of Medicine, Columbia University Irving Medical Center, New York, New York.
Mark S LachsDepartment of Medicine, Weill Cornell Medicine, New York, New York.
Monika M SaffordDepartment of Medicine, Weill Cornell Medicine, New York, New York.
Parag GoyalDepartment of Medicine, Weill Cornell Medicine, New York, New York. Electronic address: pag9051@med.cornell.edu.
Cornell University · USColumbia University Irving Medical Center · USGeorge Washington University · USThe University of Texas Health Science Center at Houston · USUniversity of Alabama at Birmingham · USUniversity of Colorado Anschutz Medical Campus · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
REGARDS - MI StudyR01HL080477 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITAN, EMILY B, SAFFORD, MONIKA M · 2006 to 2020
$11.6M
U.S. Deprescribing Research NetworkR24AG064025 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BOYD, CYNTHIA MELINDA, STEINMAN, MICHAEL A. · 2019 to 2023
$9.9M
Prescribing cascades in older adults with and without dementiaK24AG049057 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEINMAN, MICHAEL A. · 2015 to 2025
$1.8M
A Novel Deprescribing Intervention for Heart Failure with Preserved Ejection Fraction (HFpEF): A Prototype for Older Adults with Multimorbidity and PolypharmacyK76AG064428 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI GOYAL, PARAG · 2020 to 2024
$1.1M
Impact of Polypharmacy on Rehospitalization in Older Adults with Heart FailureR03AG056446 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI GOYAL, PARAG · 2017 to 2018
$265k
NHLBI NIH HHS R01 HL080477NIA NIH HHS K24 AG049057NIA NIH HHS K76 AG064428NIA NIH HHS R03 AG056446NIA NIH HHS R24 AG064025NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

backgroundWe sought to better understand patterns of potentially inappropriate medications (PIMs) from the Beers criteria among older adults hospitalized with heart failure (HF). This observational study of hospitalizations was derived from the geographically diverse REasons for Geographic and Racial Differences in Stroke cohort. METHODS AND

resultsWe examined participants aged 65 years and older with an expert-adjudicated hospitalization for HF. The Beers criteria medications were abstracted from medical records. The prevalence of PIMs was 61.1% at admission and 64.0% at discharge. Participants were taking a median of 1 PIM (interquartile range [IQR] 0-1 PIM) at hospital admission and a median of 1 PIM (IQR 0-2 PIM) at hospital discharge. Between admission and discharge, 19.1% of patients experienced an increase in the number of PIMs, 15.1% experienced a decrease, and 37% remained on the same number between hospital admission and discharge. The medications with the greatest increase from admission to discharge were proton pump inhibitors (32.6% to 38.6%) and amiodarone (6.2% to 12.2%). The strongest determinant of potentially harmful prescribing patterns was polypharmacy (relative risk 1.34, 95% confidence interval 1.16-1.55, P < .001).

conclusionsPIMs are common among older adults hospitalized for HF and may be an important target to improve outcomes in this vulnerable population.

Indexed as

Heart FailurePotentially Inappropriate Medication ListAgedHospitalizationHumansInappropriate PrescribingPrescriptionsadverse reactionsPIMs

Identifiers

PMID34818566
PMCPMC9344978
OpenAlexW3217248217

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.