ArticleCell reports2021
ILC3s control airway inflammation by limiting T cell responses to allergens and microbes.
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Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Understanding the Variability of Peanut-Oral Immunotherapy Responses by Multi-Omics Profiling of Immune Cells.Allergy · 2025Trial
- Article
- B7 costimulation antagonizes RORγt+ regulatory T cells and immune tolerance in the intestine.The Journal of experimental medicine · 2026Article
- RORγtNature communications · 2026Article
- T helper 17 cells and group 3 innate lymphoid cells define a spectrum of psoriasis endotypes.Frontiers in immunology · 2026Review
- The Antigen Presenting Capabilities of Group 3 Innate Lymphoid Cells: Insights Into Immunogenic or Tolerogenic Outcomes for T Cells.European journal of immunology · 2025Review
- The interaction network between group 3 innate lymphoid cells and other cells.Fundamental research · 2025Review
- Microbiota-mediated mechanisms of mucosal immunity across the lifespan.Nature immunology · 2025Review
- RORγt-APCs: The New Masters of Oral Tolerance.Barrier immunity · 2025Article
- The transcription factor IRF4 regulates the homeostasis and function of intestinal ILC3s.iScience · 2025Article
- Decoding innate lymphoid cells and innate-like lymphocytes in asthma: pathways to mechanisms and therapies.Journal of biomedical science · 2025Review
- RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Chronic Inflammation in Asthma: Looking Beyond the Th2 Cell.Immunological reviews · 2025Review
- MHC class II of different non-professional antigen-presenting cells mediate multiple effects of crosstalk with CD4Frontiers in medicine · 2025Review
- Group 3 Innate Lymphoid Cells: A Potential Therapeutic Target for Steroid Resistant Asthma.Clinical reviews in allergy & immunology · 2024Review
- Article
- The emerging family of RORγtNature reviews. Immunology · 2024Review
- Bcl6 is a subset-defining transcription factor of lymphoid tissue inducer-like ILC3.Cell reports · 2023Article
- IL-23 receptor signaling licenses group 3-like innate lymphoid cells to restrict a live-attenuated oral Chlamydia vaccine in the gut.Infection and immunity · 2023Article
- Innate lymphoid cells-Underexplored guardians of immunity.PLoS pathogens · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Fei TengJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Roser Tachó-PiñotLydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Biin SungDepartment of Pediatrics, Weill Cornell Medicine, New York, New York, USA.
Donna L FarberColumbia Center for Translational Immunology and Departments of Surgery and Microbiology and Immunology, Columbia University Medical Center, New York, New York, USA.
Stefan WorgallDepartment of Pediatrics, Weill Cornell Medicine, New York, New York, USA; Department of Genetic Medicine, Weill Cornell Medicine, New York, New York, USA; Drukier Institute for Children's Health, Weill Cornell Medicine, New York, New York, USA.
Hamida HammadLaboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Bart N LambrechtLaboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Department of Pulmonary Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
Matthew R HepworthLydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK. Electronic address: matthew.hepworth@manchester.ac.uk.
Gregory F SonnenbergJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA. Electronic address: gfsonnenberg@med.cornell.edu.
Cornell University · USGhent University Hospital · BEManchester Academic Health Science Centre · GBColumbia University Irving Medical Center · US
Funding
Transcriptomics and Repertoire ProfilingP01AI106697 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2013 to 2026
$31.3MRegulation of protective immunity following enteric viral infectionU01AI095608 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID, SONNENBERG, GREGORY F · 2011 to 2025
$11.0MInterleukin-2 regulation of mucosal inflammationR01AI145989 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SONNENBERG, GREGORY F · 2019 to 2025
$5.3MImmune regulation of intestinal health and diseaseR01AI123368 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Gregory F Sonnenberg · 2016 to 2026
$3.6MNeuro-immune regulation of intestinal inflammationR01DK126871 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2020 to 2024
$3.2MInnate immune regulation of neuroinflammationR01AI162936 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SONNENBERG, GREGORY F · 2021 to 2025
$3.1MDefining a novel mechanism of mucosal healingR01AI143842 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SONNENBERG, GREGORY F · 2019 to 2023
$2.5MDefining host-microbiota interactions during colorectal cancer and immune checkpoint blockadeR21CA249274 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SONNENBERG, GREGORY F · 2020 to 2021
$436kBiotechnology and Biological Sciences Research Council BB/T014482/1NCI NIH HHS R21 CA249274NIAID NIH HHS P01 AI106697NIAID NIH HHS R01 AI123368NIAID NIH HHS R01 AI143842NIAID NIH HHS R01 AI145989NIAID NIH HHS R01 AI162936NIAID NIH HHS U01 AI095608NIDDK NIH HHS R01 DK126871Wellcome TrustWellcome Trust 105644/Z/14/Z
Abstract
Group 3 innate lymphoid cells (ILC3s) critically regulate host-microbe interactions in the gastrointestinal tract, but their role in the airway remains poorly understood. Here, we demonstrate that lymphoid-tissue-inducer (LTi)-like ILC3s are enriched in the lung-draining lymph nodes of healthy mice and humans. These ILC3s abundantly express major histocompatibility complex class II (MHC class II) and functionally restrict the expansion of allergen-specific CD4
Indexed as
Adaptive ImmunityAllergensAnimalsAsthmaCD4-Positive T-LymphocytesCytokinesFemaleHost Microbial InteractionsHumansImmunity, InnateInflammationLungLymph NodesLymphocytesMaleMiceAllergensCytokinesairway inflammationantigen presentationasthmahouse dust miteILC3sinnate lymhoid cellsmicrobiotaTh17 cellstype 2 immunity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.