Evidence map›Paper›PMID 34818547›Full record

ArticleCell reports2021

Loop extrusion promotes an alternate pathway for isotype switching.

Hong Ming Shen, Robert Wuerffel, Jose F Cantillo, Saurabh Priyadarshi, Xue Lei, Jie Liang, Yee Ling Wu, Amy L Kenter

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  6. Orientation Regulation of Class-switch Recombination in Human B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hong Ming ShenDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL 60612-7344, USA.
Robert WuerffelDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL 60612-7344, USA.
Jose F CantilloDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL 60612-7344, USA.
Saurabh PriyadarshiDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL 60612-7344, USA.
Xue LeiDepartment of Bioengineering, University of Illinois Colleges of Engineering and Medicine, Chicago, IL 60612-7344, USA.
Jie LiangDepartment of Bioengineering, University of Illinois Colleges of Engineering and Medicine, Chicago, IL 60612-7344, USA.
Yee Ling WuDepartment of Microbiology and Immunology, Loyola University Chicago, Maywood, IL 60153, USA.
Amy L KenterDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL 60612-7344, USA. Electronic address: star1@uic.edu.
University of Illinois Urbana-Champaign · USLoyola University Chicago · US

Funding

Chromatin infrastructure of the Igh locus and its influence on VH gene usageR01AI121286 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KENTER, AMY L · 2016 to 2020
$4.2M
Models and Algorithms for Biological Networks and Polymers: Stochastic Probability Landscape and Chromatin EnsemblesR35GM127084 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIANG, JIE · 2018 to 2025
$3.7M
Analysis of Mbd4 function during the generation of Ig diversityR21AI133050 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KENTER, AMY L · 2017 to 2018
$440k
Identification of a CSR specific checkpointR21AI151892 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KENTER, AMY L · 2020 to 2021
$440k
Constructing Ensembles of 3D Structures of Igh Locus and Predicting Novel Chromosomal InteractionsR21AI126308 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIANG, JIE · 2017 to 2018
$421k
NIAID NIH HHS R01 AI121286NIAID NIH HHS R21 AI126308NIAID NIH HHS R21 AI133050NIAID NIH HHS R21 AI151892NIGMS NIH HHS R35 GM127084
6 · The paper itself

Abstract

Class-switch recombination (CSR) involves replacement of the Cμ constant region with another downstream C

Indexed as

AnimalsB-LymphocytesChromatinChromosome PairingCytidine DeaminaseDNA BreaksImmunoglobulin Class SwitchingImmunoglobulin EImmunoglobulin Heavy ChainsLymphocyte ActivationMaleMiceMice, Inbred BALB CMice, Inbred C57BLPromoter Regions, GeneticRecombination, GeneticChromatinCytidine DeaminaseImmunoglobulin EImmunoglobulin Heavy ChainsAID targetingB cellsBCR-negative B cellschromatin loopingDNA breaksIgEimmunoglobulin class switch recombinationloop extrusionsequential switching

Identifiers

PMID34818547
PMCPMC8979556
OpenAlexW3215067921

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.