ArticleCell reports2021
Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine.
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Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
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Who cites it
41 citing papers in PubMed, 53 citations in OpenAlex.
- The β2αB loop determines NAD(P) cofactor specificity and kinetics in trypanosomal D-3-hydroxybutyrate dehydrogenases.Journal of molecular biology · 2026Article
- The impact of microbial metabolites on host chromatin and epigenetic regulation.Nature metabolism · 2026Review
- Fasting primes small intestinal regeneration after damage via a microbiome-metabolite-chromatin axis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The effects of β-caryophyllene on butyrate utilization and metabolism in Caco-2 cells.Scientific reports · 2026Article
- HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer's disease.Experimental & molecular medicine · 2026Article
- A microbiota-IPA axis facilitates intestinal stem cell-mediated regeneration in colitis through a Hopx-associated program.Nature communications · 2026Article
- Diet-induced chromatin states influence intestinal stem cell memory.bioRxiv : the preprint server for biology · 2026Article
- TIGAR maintains intestinal epithelial regeneration by stabilizing HMGCL and promoting β-catenin β-hydroxybutyrylation in burn-induced sepsis.Cell death & disease · 2026Article
- Early-life ketone body signalling promotes beige fat biogenesis through changes in histone acetylome and β-hydroxybutyrylome.Nature metabolism · 2025Article
- Ketone body β-hydroxybutyrate-mediated histone β-hydroxybutyrylation upregulates lipolysis and attenuates metabolic syndrome.American journal of physiology. Cell physiology · 2025Article
- ACSS2 coupled with KAT7 regulates histone β-hydroxybutyrylation to enhance transcription.Science advances · 2025Article
- A Small-Molecule Compound Targeting Canine Mammary Cancer Regulates CXCL10 and MECOM Transcripts via Histone Modifications in CMT-N7.Animals : an open access journal from MDPI · 2025Article
- The LncRNA STEAP3-AS1 promotes liver metastasis in colorectal cancer by regulating histone lactylation through chromatin remodelling.Journal of experimental & clinical cancer research : CR · 2025Article
- SIRT3 Functions as an Eraser of Histone H3K9 Lactylation to Modulate Transcription for Inhibiting the Progression of Esophageal Cancer.Molecular & cellular proteomics : MCP · 2025Article
- Not Just an Alternative Energy Source: Diverse Biological Functions of Ketone Bodies and Relevance of HMGCS2 to Health and Disease.Biomolecules · 2025Review
- Natural killer cells' functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes.Nature communications · 2025Article
- Dietary and metabolic effects on intestinal stem cells in health and disease.Nature reviews. Gastroenterology & hepatology · 2025Review
- From ketogenic metabolism to targeted therapeutics: current advances in β-hydroxybutyrylation.Frontiers in immunology · 2025Review
- Histone β-hydroxybutyrylation is critical in reversal of sarcopenia.Aging cell · 2024Article
- Dietary Organic Zinc Supplementation Modifies the Oxidative Genes via RORγ and Epigenetic Regulations in the Ileum of Broiler Chickens Exposed to High-Temperature Stress.Antioxidants (Basel, Switzerland) · 2024Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Christopher J TerranovaDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Kristina M StemlerDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Praveen BarrodiaDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Sabrina L Jeter-JonesDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Zhongqi GeDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Marimar de la Cruz BonillaDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Ayush RamanDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Epigenomics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Chia-Wei ChengKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.
Kendra L AlltonDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Emre ArslanDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Ömer H YilmazKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.
Michelle C BartonDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Kunal RaiDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: krai@mdanderson.org.
Helen Piwnica-WormsDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: hpiwnica-worms@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USAllen Institute · USBroad Institute · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MFasting Protects Small Intestinal Stem Cells from Lethal DNA Damage: Mechanistic Insight and Preclinical TranslationR01CA207236 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PIWNICA-WORMS, HELEN M · 2017 to 2021
$2.4MUCHL5 as a regulator and therapeutic target in metastatic melanomaR01CA245395 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI RAI, KUNAL · 2020 to 2024
$2.0MTraining Grant in Cancer BiologyT32CA186892 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KALLURI, RAGHU · 2016 to 2020
$1.1MElucidating the role of fasting in intestinal stemness and tissue regenerationR00DK123407 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHENG, CHIA-WEI · 2021 to 2023
$727kElucidating the Role of Fasting in GI Radioprotection: Applications in Pre-Clinical Pancreatic Cancer ModelF31CA210631 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DE LA CRUZ BONILLA, MARIMAR · 2017 to 2018
$58kNCI NIH HHS F31 CA210631NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA207236NCI NIH HHS R01 CA245395NCI NIH HHS T32 CA186892NIDDK NIH HHS R00 DK123407
Abstract
β-hydroxybutyrate (β-OHB) is an essential metabolic energy source during fasting and functions as a chromatin regulator by lysine β-hydroxybutyrylation (Kbhb) modification of the core histones H3 and H4. We report that Kbhb on histone H3 (H3K9bhb) is enriched at proximal promoters of critical gene subsets associated with lipolytic and ketogenic metabolic pathways in small intestine (SI) crypts during fasting. Similar Kbhb enrichment is observed in Lgr5
Indexed as
3-Hydroxybutyric AcidAcetylationAnimalsChromatinFastingFemaleGene ExpressionGene Expression RegulationHistonesIntestine, SmallKetone BodiesLysineMaleMiceMice, Inbred C57BLPromoter Regions, Genetic3-Hydroxybutyric Acidbeta-lysineChromatinHistonesKetone BodiesLysinechromatin statesfasting responsegene expressionhistone modificationsketogenicsmall intestine cryptsβ-hydroxybutyrate
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.