ArticleNeuron2022
Context-dependent persistency as a coding mechanism for robust and widely distributed value coding.
Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
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- Adaptive reorganization of history encoding in the retrosplenial cortex supports flexible decision-making strategies.Neuron · 2026Article
- Meta-learning is expressed through altered prefrontal cortical dynamics.bioRxiv : the preprint server for biology · 2026Article
- Anterior and posterior retrosplenial cortex form distinct visuospatial circuits in the mouse.Nature communications · 2026Article
- Time-dependent deployment of medial prefrontal cortical representations in male mice.Nature communications · 2026Article
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- Learning Temporal Relationships Between Symbols with Laplace Neural Manifolds.Computational brain & behavior · 2025Article
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- Distinct manifold encoding of navigational information in the subiculum and hippocampus.Science advances · 2024Article
- Dopamine-independent effect of rewards on choices through hidden-state inference.Nature neuroscience · 2024Article
- Automating licking bias correction in a two-choice delayed match-to-sample task to accelerate learning.Scientific reports · 2023Article
- Exponential history integration with diverse temporal scales in retrosplenial cortex supports hyperbolic behavior.Science advances · 2023Article
- Meta-reinforcement learning via orbitofrontal cortex.Nature neuroscience · 2023Article
- Mixtures of strategies underlie rodent behavior during reversal learning.PLoS computational biology · 2023Article
- A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions.Nature communications · 2023Article
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Abstract
Task-related information is widely distributed across the brain with different coding properties, such as persistency. We found in mice that coding persistency of action history and value was variable across areas, learning phases, and task context, with the highest persistency in the retrosplenial cortex of expert mice performing value-based decisions where history needs to be maintained across trials. Persistent coding also emerged in artificial networks trained to perform mouse-like reinforcement learning. Persistency allows temporally untangled value representations in neuronal manifolds where population activity exhibits cyclic trajectories that transition along the value axis after action outcomes, collectively forming cylindrical dynamics. Simulations indicated that untangled persistency facilitates robust value retrieval by downstream networks. Even leakage of persistently maintained value through non-specific connectivity could contribute to the brain-wide distributed value coding with different levels of persistency. These results reveal that context-dependent, untangled persistency facilitates reliable signal coding and its distribution across the brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.