Evidence map›Paper›PMID 34818503›Full record

ArticleACS applied materials & interfaces2021

Surface-Catalyzed Nitric Oxide Release via a Metal Organic Framework Enhances Antibacterial Surface Effects.

Mark Garren, Patrick Maffe, Alyssa Melvin, Lauren Griffin, Sarah Wilson, Megan Douglass, Melissa Reynolds, Hitesh Handa

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 57 citations in OpenAlex.

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  15. PreventingACS applied bio materials · 2024
    Article
  16. ACS applied materials & interfaces · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mark GarrenSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Patrick MaffeSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Alyssa MelvinDepartment of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
Lauren GriffinSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Sarah WilsonSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Megan DouglassSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Melissa ReynoldsDepartment of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.ORCID https://orcid.org/0000-0002-1836-7324
Hitesh HandaSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.ORCID https://orcid.org/0000-0002-9369-7374
University of Georgia · USColorado State University · US

Funding

TRD3 NMRbox: Bayesian AnalyticsP41GM111135 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HOCH, JEFFREY C · 2015 to 2024
$14.0M
Engineering nitric oxide releasing polymer with immobilized thrombin inhibitor for blood contacting applicationsR01HL134899 · NHLBI · UNIVERSITY OF GEORGIA · PI HANDA, HITESH · 2017 to 2025
$3.0M
Metal organic framework-based antithrombotic surfacesR01HL140301 · NHLBI · COLORADO STATE UNIVERSITY · PI HANDA, HITESH, REYNOLDS, MELISSA M · 2018 to 2021
$1.4M
NHLBI NIH HHS R01 HL134899NHLBI NIH HHS R01 HL140301NIGMS NIH HHS P41 GM111135
6 · The paper itself

Abstract

It has been previously demonstrated that metal nanoparticles embedded into polymeric materials doped with nitric oxide (NO) donor compounds can accelerate the release rate of NO for therapeutic applications. Despite the advantages of elevated NO surface flux for eradicating opportunistic bacteria in the initial hours of application, metal nanoparticles can often trigger a secondary biocidal effect through leaching that can lead to unfavorable cytotoxic responses from host cells. Alternatively, copper-based metal organic frameworks (MOFs) have been shown to stabilize Cu

Indexed as

Anti-Bacterial AgentsBiomimetic MaterialsCatalysisCells, CulturedCopperHumansMaterials TestingMetal-Organic FrameworksMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular ConformationNitric OxideNitric Oxide DonorsParticle SizeSurface PropertiesAnti-Bacterial AgentsCopperMetal-Organic FrameworksNitric OxideNitric Oxide Donorscatalysisinfectionmetal organic frameworknitric oxideS-nitrosothiols

Identifiers

PMID34818503
PMCPMC9728615
OpenAlexW3216324155

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.