Evidence map›Paper›PMID 34818416›Full record

ArticleBlood2022

RACGAP1 variants in a sporadic case of CDA III implicate the dysfunction of centralspindlin as the basis of the disease.

Sandeep N Wontakal, Mishan Britto, Huan Zhang, Yongshuai Han, Chengjie Gao, Sarah Tannenbaum, Benjamin H Durham, Margaret T Lee, Xiuli An, Masanori Mishima

Abstract read
In one paragraph

Article in Blood, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Hereditary disorders of ineffective erythropoiesis.Blood cells, molecules & diseases · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Mutations in theHaematologica · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sandeep N WontakalDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0003-0889-032X
Mishan BrittoCentre for Mechanochemical Cell Biology & Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Huan ZhangLaboratory of Membrane Biology, New York Blood Center, New York, NY.
Yongshuai HanLaboratory of Membrane Biology, New York Blood Center, New York, NY.
Chengjie GaoLaboratory of Membrane Biology, New York Blood Center, New York, NY.
Sarah TannenbaumDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY; and.
Benjamin H DurhamDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0001-8090-5448
Margaret T LeeDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY; and.
Xiuli AnLaboratory of Membrane Biology, New York Blood Center, New York, NY.
Masanori MishimaCentre for Mechanochemical Cell Biology & Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom.ORCID 0000-0002-8908-7485

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Sickle cell bone marrow niche and regulation of platelet activation and erythropoiesisP01HL149626 · NHLBI · NEW YORK BLOOD CENTER · PI Karina Yazdanbakhsh · 2020 to 2026
$24.4M
Use of forward Genetic approaches to identify Babesia receptorsR01HL140625 · NHLBI · NEW YORK BLOOD CENTER · PI AN, XIULI, LOBO, CHERYL ANN · 2018 to 2021
$2.8M
Elucidating the Spatiotemporal Regulation of a Long Non-Coding RNA Required for NeurodevelopmentK08NS119567 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WONTAKAL, SANDEEP NAGARAJ · 2021 to 2025
$1.1M
Cancer Research UK C19769/A11985NCI NIH HHS P30 CA008748NHLBI NIH HHS P01 HL149626NHLBI NIH HHS R01 HL140625NINDS NIH HHS K08 NS119567
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anemia, Dyserythropoietic, CongenitalGTPase-Activating ProteinsHumansGTPase-Activating ProteinsmgcRacGAP

Identifiers

PMID34818416
PMCPMC8900277

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.