Evidence map›Paper›PMID 34818059›Full record

ArticleScience translational medicine2021

Oxidative damage and delayed replication allow viable

Kohta Saito, Saurabh Mishra, Thulasi Warrier, Nico Cicchetti, Jianjie Mi, Elaina Weber, Xiuju Jiang, Julia Roberts, Alexandre Gouzy, Ellen Kaplan and 3 more

Abstract read
In one paragraph

Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. MakingCell insight · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Beyond culturability: VBNC-like and differentially culturableFrontiers in cellular and infection microbiology · 2026
    Review
  7. Article
  8. Reactive Oxygen Detoxification Contributes tobioRxiv : the preprint server for biology · 2025
    Article
  9. Review
  10. Article
  11. Candidate transmission survival genome ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Eradication of Drug-TolerantMicroorganisms · 2023
    Review
  16. Intracellular persister: A stealth agent recalcitrant to antibiotics.Frontiers in cellular and infection microbiology · 2023
    Review
  17. The performance of tongue swabs for detection of pulmonary tuberculosis.Frontiers in cellular and infection microbiology · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kohta SaitoDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0002-2190-4127
Saurabh MishraDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0003-1590-884X
Thulasi WarrierDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0002-4384-0873
Nico CicchettiDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10021, USA.
Jianjie MiDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0001-7136-8118
Elaina WeberDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0002-3551-930X
Xiuju JiangDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10021, USA.
Julia RobertsDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0002-9329-4671
Alexandre GouzyDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0001-6671-7408
Ellen KaplanDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0002-5706-2806
Christopher D BrownDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0003-2182-8133
Ben GoldDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0002-9562-8241
Carl NathanDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0002-7744-8896

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Richard Lewis Possemato · 1985 to 2026
$83.1M
Viable but Nonculturable MtbU19AI111143 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI GLICKMAN, MICHAEL S, NATHAN, CARL FRANCIS · 2014 to 2020
$48.6M
T32: Pathogenesis of Infectious Diseases Training ProgramT32AI007613 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROY M. GULICK · 1999 to 2026
$8.8M
The Transmission Biology of Mycobacterium TuberculosisK08AI148584 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI BROWN, CHRISTOPHER DAVID · 2021 to 2025
$974k
Identifying the Molecular Target of Two Novel Compounds Active Against Non-replicating Mycobacterium tuberculosis and Delineating the Role of the Putative Target, InhA, in Non-replicating StatesK08AI139360 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAITO, KOHTA · 2019 to 2023
$860k
NCI NIH HHS P30 CA016087NIAID NIH HHS K08 AI139360NIAID NIH HHS K08 AI148584NIAID NIH HHS T32 AI007613NIAID NIH HHS U19 AI111143
6 · The paper itself

Abstract

“Viable but nonculturable” states of bacteria pose challenges for environmental and clinical microbiology, but their biological mechanisms remain obscure.

Indexed as

COVID-19Mycobacterium tuberculosisTuberculosisHumansOxidative StressSARS-CoV-2

Identifiers

PMID34818059
PMCPMC8903021

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.