ArticleLiver international : official journal of the International Association for the Study of the Liver2022
Sarcopenia is highly prevalent in children with autoimmune liver diseases and is linked to visceral fat and parent-perceived general health.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Sarcopenia in pediatric gastroenterology and hepatology: an updated review.Clinical and experimental pediatrics · 2026Article
- Comparison of body composition between thin and normal-weight sarcopenic children: a single-center, propensity score matching analysis of a large-scale study.BMC pediatrics · 2026Article
- Skeletal muscle fatty deposition in young and middle-aged adults with metabolic dysfunction-associated fatty liver disease: a magnetic resonance proton density fat fraction study.Quantitative imaging in medicine and surgery · 2025Article
- Bioelectrical impedance analysis for measuring body composition and predicting low muscle mass in apparently healthy pediatric outpatients: a retrospective observational study.BMC pediatrics · 2025Observational
- Impact of sarcopenia on clinical outcomes in pediatric chronic liver disease post-liver transplantation: prevalence and implications.Gastroenterology and hepatology from bed to bench · 2024Article
- Review
- Can Biological Drugs Diminish the Risk of Sarcopenia in Psoriatic Patients? A Systematic Review.Life (Basel, Switzerland) · 2022Review
- Impact of Sarcopenia and Myosteatosis in Non-Cirrhotic Stages of Liver Diseases: Similarities and Differences across Aetiologies and Possible Therapeutic Strategies.Biomedicines · 2022Review
- Perspectives on Sarcopenia as a Predictor for Outcomes in Pediatric Patients with Chronic Liver Disease.Hepatic medicine : evidence and research · 2022Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPatients with autoimmune hepatitis (AIH) and primary or autoimmune sclerosing cholangitis are at nutritional risk; their body composition and has not been extensively studied. We aimed to describe their body composition and identify clinical links.
methodsUsing magnetic resonance imaging (MRI), two reviewers segmented total psoas muscle area (tPMSA), visceral fat area (VFA) and subcutaneous fat area (mm
resultsFifty-eight patients with autoimmune liver disease (AILD) (33 [57%] with AIH) were included: median age 16 years (interquartile range [IQR]: 13-18), 33 (57%) male. Median time from diagnosis to MRI was 15 months (IQR: 2-39 months). Two patients (3%) had a BMIz indicative of mild malnutrition. tPMSA was measurable in 52 subjects (90%). Of those, 25 (48%) had sarcopenia. Sarcopenic patients had a lower blood urea nitrogen compared to non-sarcopenic (median [IQR]: 9.5 [8.0, 12.0] vs 11 [10, 14] mg/dL; P = .023). There was no difference in corticosteroid use between groups. The VFA of sarcopenic patients was higher (3156 [2064, 7492]) vs 2084 [688, 3092]) mm
conclusionIn autoimmune liver diseases, sarcopenia is highly prevalent, associated with increased visceral fat and QoL.
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