ArticleInfectious diseases and therapy2022
Predictors of Complications Secondary to Infective Endocarditis and Their Associated Outcomes: A Large Cohort Study from the National Emergency Database (2016-2018).
Article in Infectious diseases and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Infective endocarditis complicated by shock: a systematic review and meta-analysis.Heart failure reviews · 2025Pooled it
- Contemporary Clinical Spectrum and Factors Associated with Mortality in Infective Endocarditis: A Multicenter Cohort Study (COSMO-IE).Journal of clinical medicine · 2026Article
- Development and validation of a machine learning model for predicting 6-month mortality in patients with infective endocarditis.Biomedical engineering online · 2026Article
- Predictors of In-Hospital Mortality From Infective Endocarditis in a Resource-Limited, War-Affected Tertiary Center.Reviews in cardiovascular medicine · 2026Article
- Infective Endocarditis and Complications; Surgical Indications and Management: An Integrative Review.Journal of personalized medicine · 2026Review
- Association between prothrombin time activity and short-term outcomes in patients with infective endocarditis.BMC infectious diseases · 2026Article
- Acute heart failure in infective endocarditis treated with valve-in-valve transcatheter aortic valve implantation.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2025Article
- Article
- Multiple Imaging Modalities in the Diagnosis of Infective Endocarditis.Reviews in cardiovascular medicine · 2025Review
- Review
- Prediction of hospital mortality in patients with left-sided infective endocarditis using a score in the first hours of admission.Scientific reports · 2025Article
- Effects of Warfarin on the Risks of Mortality, Acute Heart Failure, and Infection Resolution in Patients With Infective Endocarditis: A Target Trial Emulation.Journal of the American Heart Association · 2025Observational
- Anemia and Transfusion in Infective Endocarditis.Reviews in cardiovascular medicine · 2025Review
- Infective Endocarditis in Septic Shock: Results From an Observational Multicenter Study.Cureus · 2025Article
- Infective Endocarditis-Predictors of In-Hospital Mortality, 17 Years, Single-Center Experience in Bulgaria.Microorganisms · 2024Article
- Atypical Infective Endocarditis Presenting With Euthermia and Right Lower Quadrant Abdominal Pain.Cureus · 2024Article
- Beyond the Valve: Incidence, Outcomes, and Modifiable Factors of Acute Kidney Injury in Patients with Infective Endocarditis Undergoing Valve Surgery-A Retrospective, Single-Center Study.Journal of clinical medicine · 2024Article
- Clinical Features and Patient Outcomes in Infective Endocarditis with Surgical Indication: A Single-Centre Experience.Journal of cardiovascular development and disease · 2024Article
- Perioperative Complications in Infective Endocarditis.Journal of clinical medicine · 2023Review
- Intraoperative Cell Savage, Infection and Organ Failure in Infective Endocarditis Patients-A Retrospective Single Center Evaluation.Journal of clinical medicine · 2023Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
introductionLiterature regarding outcomes and predictors of complications secondary to infective endocarditis (IE) is limited. We aimed to study the outcomes and predictors of complications of IE.
methodsData from a national emergency department sample, which constitutes 20% sample of hospital-owned emergency departments in the USA, were analyzed for hospital visits for IE. Complications of endocarditis were obtained by using ICD codes. Multivariable generalized linear method was used to evaluate predictors of in-hospital mortality and complications.
resultsOut of 255,838 adult IE patients (mean age 60.3 ± 20.1 years, 48.5% females), 97,803 (38.2%) patients developed one or more major complications. The major complications were cardiovascular system complications [57,900 (22.6%)], neurologic [42,851 (16.7%)] complications, and renal [16,236 (6.4%)] complications. These included cardiogenic shock [3873 (1.5%)], septic shock [25,798 (10.1%)], acute heart failure [35,602 (14%)], systemic thromboembolism (STE) [21,390 (8.36%)], heart block [11,430 (4.47%)], in-hospital dialysis [2880 (1.1%)], and disseminated intravascular coagulation (DIC) [2704 (1.1%)]. Patients with complicated IE had risk of mortality (adjusted RR 1.12, 95% CI 1.11-1.13, p < 0.001). The complications strongly associated with mortality were septic shock (RR 1.29, 95% CI 1.27-1.30, p < 0.001), cardiogenic shock (RR 1.24, 95% CI 1.20-1.29, p < 0.001), DIC (RR 1.4, 95% CI 1.35-1.46, p < 0.001), and STE (RR 1.07, 95% CI 1.05-1.08, p < 0.001). Staphylococci were the predominant causative organisms (30.8%) among the complicated IE subgroups with higher associated mortality (42.8%). The main predictors of complications from IE were congenital heart disease, history of congestive heart failure, high Elixhauser comorbidity profile, staphylococcal infection, and fungal infections. The prevalence of cardiogenic shock increased over the study years from 1.13 to 1.98% (p-trend 0.04).
conclusionComplicated IE is not uncommon and is associated with significant mortality. Staphylococcal infections were associated with high mortality rates. There has been an increasing trend of cardiogenic shock among IE patients across the US. Further research is needed to improve the outcomes of complicated endocarditis.
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