Evidence map›Paper›PMID 34817810›Full record

ArticleCardiovascular toxicology2022

Yohimbine Directly Induces Cardiotoxicity on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Yiqi Gong, Li Yang, Jun Tang, Jijian Zheng, Nevin Witman, Philipp Jakob, Yao Tan, Minglu Liu, Ying Chen, Huijing Wang and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Cardiovascular toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Multifaced Nature of Yohimbine-A Promising Therapeutic Potential or a Risk?International journal of molecular sciences · 2024
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Yiqi Gong *Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, China.
Li Yang *Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Jun Tang *Department of Anesthesiology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, 200240, China.
Jijian ZhengDepartment of Anesthesiology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Nevin WitmanDepartment of Cell and Molecular Biology, Karolinska Institute, 17177, Stockholm, Sweden.
Philipp JakobDepartment of Cardiology, University Heart Center, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.
Yao TanDepartment of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, China.
Minglu LiuDepartment of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, China.
Ying ChenDepartment of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, China.
Huijing WangInstitute of Pediatric Translational Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Wei FuDepartment of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, China. fuweizhulu@163.com.ORCID 0000-0003-2321-1057
Wei WangDepartment of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, China. wangwei@scmc.com.cn.
Shanghai Jiao Tong University · CNFudan University · CNKarolinska Institutet · SEShanghai Medical College of Fudan University · CNUniversity of Zurich · CH

Funding

health commission of minhang district, shanghai 2018MW02national key r&d program of china (2019YFA0110400)national natural science foundation of china 82070430natural science foundation of shanghai 20ZR1434500shanghai collaborative innovation center for translational medicine TM201821shanghai pujiang program 18PJD031shanghai science and technology development foundation PKJ2020-Y06the biomedical engineering fund of shanghai jiao tong university YG2021GD04
6 · The paper itself

Abstract

Yohimbine is a highly selective and potent α

Indexed as

Action PotentialsAdrenergic alpha-2 Receptor AntagonistsArrhythmias, CardiacCalcium ChannelsCardiotoxicityCell LineDose-Response Relationship, DrugHeart RateHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsInduced Pluripotent Stem CellsMyocytes, CardiacSodium ChannelsYohimbineAdrenergic alpha-2 Receptor AntagonistsCalcium ChannelsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsSodium ChannelsYohimbineCardiotoxicityElectrophysiologyHuman-induced pluripotent stem cell-derived cardiomyocytesYohimbine

Identifiers

PMID34817810
OpenAlexW3217280487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.