Evidence map›Paper›PMID 34817796›Full record

ArticleJournal of neuro-oncology2022

Genetic modulation of longitudinal change in neurocognitive function among adult glioma patients.

Jeffrey S Wefel, Renke Zhou, Erik P Sulman, Nicholas S Boehling, Georgina N Armstrong, Spiridon Tsavachidis, Fu-Wen Liang, Carol J Etzel, Lisa S Kahalley, Brent J Small and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Jeffrey S WefelSection of Neuropsychology, Department of Neuro-Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 431, Houston, TX, 77030, USA. jwefel@mdanderson.org.ORCID http://orcid.org/0000-0003-3584-023X
Renke Zhou *Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Mailstop BCM305, Houston, TX, 77030, USA.
Erik P SulmanDepartment of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA.
Nicholas S BoehlingDepartment of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA.
Georgina N ArmstrongDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Mailstop BCM305, Houston, TX, 77030, USA.
Spiridon TsavachidisDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Mailstop BCM305, Houston, TX, 77030, USA.
Fu-Wen LiangInstitute of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Carol J EtzelBiostatistics, Corrona, LLC, Southborough, MA, 01772, USA.
Lisa S KahalleyDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, 77030, USA.
Brent J SmallSchool of Aging Studies, University of South Florida, 4202 E Fowler Avenue, Tampa, FL, 33620, USA.
Michael E ScheurerDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Mailstop BCM305, Houston, TX, 77030, USA.
Melissa L BondyDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Mailstop BCM305, Houston, TX, 77030, USA. mbondy@bcm.edu.
Yanhong LiuDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Mailstop BCM305, Houston, TX, 77030, USA. yl10@bcm.edu.
Baylor College of Medicine · USThe University of Texas MD Anderson Cancer Center · USNational Cheng Kung University · TWUniversity of South Florida · US

Funding

International Case Control Study of Malignant GliomaR01CA139020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2010 to 2015
$16.0M
Genetic Epidemiology of Glioma International ConsortiumR01CA119215 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2006 to 2010
$11.9M
MOLECULAR EPIDEMIOLOGY OF GLIOMASR01CA070917 · NCI · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI BONDY, MELISSA L · 1996 to 2004
$3.0M
Multimodal MRI Biomarker of Mild Cognitive Impairment in Breast CancerR01NR014195 · NINR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KESLER, SHELLI R, WEFEL, JEFFREY SCOTT · 2012 to 2017
$2.5M
Infection and Inflammation in Adult GliomasK07CA131505 · NCI · BAYLOR COLLEGE OF MEDICINE · PI SCHEURER, MICHAEL E. · 2008 to 2012
$784k
Lung Cancer Prediction Models Incorporating Exome Data from Extreme PhenotypesK07CA181480 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LIU, YANHONG · 2014 to 2017
$511k
Evaluating Etiological Impact of Metatranscriptomic and Immunological Features for Lung CancerR03CA262911 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LIU, YANHONG · 2021 to 2022
$160k
NCI NIH HHS K07 CA131505NCI NIH HHS K07 CA181480NCI NIH HHS R03 CA262911NIH HHS K07CA131505NIH HHS K07CA181480NIH HHS R01CA070917NIH HHS R01CA119215NIH HHS R01CA139020NIH HHS R01NR014195
6 · The paper itself

Abstract

purposeImpaired neurocognitive function (NCF) is extremely common in patients with higher grade primary brain tumor. We previously reported evidence of genetic variants associated with NCF in glioma patients prior to treatment. However, little is known about the effect of genetic variants on NCF decline after adjuvant therapy.

methodsPatients (N = 102) completed longitudinal NCF assessments that included measures of verbal memory, processing speed, and executive function. Testing was conducted in the postoperative period with an average follow up interval of 1.3 years. We examined polymorphisms in 580 genes related to five pathways (inflammation, DNA repair, metabolism, cognitive, and telomerase).

resultsFive polymorphisms were associated with longitudinal changes in processing speed and 14 polymorphisms with executive function. Change in processing speed was strongly associated with MCPH1 rs17631450 (P = 2.2 × 10

conclusionOur longitudinal analyses revealed that polymorphisms in telomerase, DNA repair, and cognitive pathways are independent predictors of decline in NCF in glioma patients.

Indexed as

Brain NeoplasmsGliomaNeurocognitive DisordersAdultDNA RepairHumansLongitudinal StudiesNeuropsychological TestsPolymorphism, GeneticTelomeraseTelomeraseChemotherapyGenetic variationGliomaNeurocognitive functionRadiation

Identifiers

PMID34817796
OpenAlexW3215276837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.