SynthesisInternational journal of colorectal disease2022
Endoscopic vacuum therapy for the treatment of colorectal leaks - a systematic review and meta-analysis.
Synthesis in International journal of colorectal disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Endoscopic Treatment Options for Gastrointestinal Leaks.Visceral medicine · 2022Pooled it
- Endoscopic vacuum therapy for anastomotic leakage after upper gastrointestinal surgery.Endoscopy · 2023Trial
- Endoscopic vacuum therapy for a refractory sigmoid fistula.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2026Article
- Article
- A Case Series and Technical Note on Endoluminal Vacuum Therapy via Pull-Through Technique for Leakage after Metabolic Bariatric Surgery.Obesity surgery · 2026Article
- Defect Size-Based Comparative Analysis of Treatment Modalities for Esophagojejunal Anastomotic Leakage Following Gastrectomy.Journal of gastric cancer · 2026Article
- Endotoxin in drainage fluid as an early and predictive marker of anastomotic leakage after colorectal surgery.Surgery today · 2026Article
- Predictors of Clinical Success in Patients Selected for Endoscopic Management of Gastrointestinal Transmural Defects.Endoscopy international open · 2026Article
- Endoscopic negative pressure therapy as a salvage treatment for management of post-surgical anastomotic leaks without ostomy after colorectal resection.Scientific reports · 2025Article
- Hospital costs of different treatment strategies for anastomotic leakage after total mesorectal excision: a multicentre cost analysis.Techniques in coloproctology · 2025Article
- Mitigating 'inevitable' anastomotic leaks in left-sided colorectal surgery: a combined strategy using indocyanine green fluorescence, intraoperative colonscopy and patient risk profiling.Updates in surgery · 2025Article
- Modified low-cost EndoVac is safe and efficacious for treatment of postoperative leaks even at low pressures.Surgical endoscopy · 2025Article
- Endoscopic Management of Anastomotic Insufficiencies in the Lower GI Tract.Visceral medicine · 2025Review
- Diagnostic Value of Postsurgical Endoscopy.Visceral medicine · 2025Review
- Endoscopic vacuum therapy for gastrointestinal transmural defects: a literature review.Clinical endoscopy · 2025Review
- Summary of the current guidelines for managing iatrogenic colorectal perforations and the evolving role of endoluminal vacuum therapy.World journal of clinical cases · 2025Article
- [Anastomotic leaks in colorectal surgery].Chirurgie (Heidelberg, Germany) · 2024Article
- Endoscopic vacuum therapy.iGIE : innovation, investigation and insights · 2024Article
- Expert commentary: unveiling a rare adverse event.iGIE : innovation, investigation and insights · 2024Article
- Endoluminal Vacuum Therapy as Effective Treatment for Patients with Postoperative Leakage After Metabolic Bariatric Surgery-A Single-Center Experience.Obesity surgery · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring the last two decades, vacuum-assisted wound therapy has been successfully transferred to an endoscopic treatment approach of various upper and lower gastrointestinal leaks called endoscopic vacuum therapy (EVT). As mostly small case series are published in this field, the aim of our systematic review and meta-analysis was to evaluate the efficacy and safety of EVT in the treatment of colorectal leaks.
methodsA systematic search of MEDLINE/PubMed and Cochrane databases was performed using search terms related to EVT and colorectal defects (anastomotic leakage, rectal stump insufficiency) according to the PRISMA guidelines. Randomized controlled trials (RCTs), observational studies, and case series published by December 2020 were eligible for inclusion. A meta-analysis was conducted on the success of EVT, stoma reversal rate after EVT as well as procedure-related complications. Statistical interferences were based on pooled estimates from random effects models using DerSimonian-Laird estimator.
resultsOnly data from observational studies and case series were available. Twenty-four studies reporting on 690 patients with colorectal defects undergoing EVT were included. The mean rate of success was 81.4% (95% CI: 74.0%-87.1%). The proportion of diverted patients was 76.4% (95% CI: 64.9%-85.0%). The mean rate of ostomy reversal across the studies was 66.7% (95% CI: 58.0%-74.4%). Sixty-four patients were reported with EVT-associated complications, the weighted mean complication rate across the studies was 12.1% (95% CI: 9.7%-15.2%).
conclusionsCurrent medical evidence on EVT in patients with colorectal leaks lacks high quality data from RCTs. Based on the data available, EVT can be seen as a feasible treatment option with manageable risks for selected patients with colorectal leaks.
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