Evidence map›Paper›PMID 34817646›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2022

Safety and efficacy of alcohol septal ablation in adolescents and young adults with hypertrophic obstructive cardiomyopathy.

Dennis Lawin, Thorsten Lawrenz, Kristin Radke, Christoph Stellbrink

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Corticosteroids reduce pacemaker implantation after alcohol septal ablation in oHCM patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dennis LawinDepartment of Cardiology and Intensive Care Medicine, Klinikum Bielefeld gemGmbH, University Hospital OWL, Teutoburger Straße 50, 33604, Bielefeld, Germany.
Thorsten LawrenzDepartment of Cardiology and Intensive Care Medicine, Klinikum Bielefeld gemGmbH, University Hospital OWL, Teutoburger Straße 50, 33604, Bielefeld, Germany.
Kristin RadkeDepartment of Cardiology and Intensive Care Medicine, Klinikum Bielefeld gemGmbH, University Hospital OWL, Teutoburger Straße 50, 33604, Bielefeld, Germany.
Christoph StellbrinkDepartment of Cardiology and Intensive Care Medicine, Klinikum Bielefeld gemGmbH, University Hospital OWL, Teutoburger Straße 50, 33604, Bielefeld, Germany. christoph.stellbrink@klinikumbielefeld.de.ORCID http://orcid.org/0000-0002-8429-2826
Klinikum Bielefeld · DEWitten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionData regarding alcohol septal ablation (ASA) in young patients with hypertrophic obstructive cardiomyopathy (HOCM) are scarce. The purpose of our study is to evaluate the safety and efficacy of ASA in patients ≤ 25 years. METHODS AND

resultsAll ASAs between 2002 and 2020 at our institution were assigned to a group of patients 14-25 years of age (group 1) and a reference group > 25 years (group 2). 1,264 procedures were analysed in group 2 (58.6 ± 13.5 years) and 41 procedures in group 1 (20.9 ± 3.3 years). The baseline interventricular septal diameter (IVSD) was higher in group 1 (26.0 ± 6.5 mm vs. 21.3 ± 4.4 mm; p < 0.0001). There was no difference in baseline left ventricular outflow tract gradient (LVOTG) (group 1: 54.4 ± 24.4 mmHg; group 2: 52.4 ± 36.6 mmHg; p = n.s.). A previous cardiac device was more often observed in group 1 (31.7% vs. 9.0%; p < 0.0001). Symptoms were improved after 6 months (group 1: mean NYHA class 2.5 at baseline and 1.3 at FU; p < 0.0001; group 2: mean NYHA class 2.7 at baseline and 1.4 at FU; p <0 .0001). IVSD (group 1: 20.3 ± 8.2 mm; group 2: 16.8 ± 5.7 mm; p < 0.0001 for each group compared to baseline) and LVOTG improved during FU (group 1: 25.5 ± 20.0 mmHg; group 2: 22.1 ± 21.7 mmHg; p < 0.0001 for each group). Intrahospital mortality was 0.0% in patients 14-25 years and 0.9% in the reference group. Persistent AV-block was observed in 12.2% of the group 1 and 15.9% of the group 2 patients (p = n.s.).

conclusionASA is safe and effective in HOCM patients 14-25 years of age in experienced centres.

Indexed as

Ablation TechniquesAdolescentAdultAtrioventricular BlockCardiomyopathy, HypertrophicEthanolFemaleHumansMaleRetrospective StudiesTreatment OutcomeVentricular SeptumYoung AdultEthanolAdolescentsAlcohol septal ablationHypertrophic obstructive cardiomyopathyOutcomeYoung adults

Identifiers

PMID34817646
OpenAlexW3215521863

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.